The Registry of Toxic Effects of Chemical Substances

Benzene, bromo -

RTECS #: CY9000000

CAS #: 108-86-1

UPDATE: November 2004 MW: 157.02 MF: C6H5Br


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. NCI - C55492
  2. Monobromobenzene
  1. Phenyl bromide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Escherichia coli 250 mg/L JJIND8 62,873,1979
micronucleus test intraperitoneal
mouse 		125 mg/kg/24 hour MUTAEX 2,111,1987
sister chromatid exchange hamster ovary 500 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 14,400 mg/m3 N/R GTPZAB 18(4),55,1974
inhalation
mouse 		lethal concentration (50 percent kill): 21 gm/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity 		GTPZAB 13(9),56,1969
inhalation
rat 		lethal concentration (50 percent kill): 20,411 mg/m3 N/R GTPZAB 19(9),36,1975
inhalation
rat 		lowest published toxic concentration: 250 mg/m3 Blood: Changes in cell count (unspecified) VCVGK* -,47,1984
intraperitoneal
mouse 		lethal dose (50 percent kill): 817 mg/kg N/R MUTAEX 2,111,1987
intraperitoneal
mouse 		lowest published lethal dose: 0.5 ml/kg N/R TOSCF2 73,220,2003
intraperitoneal
rat 		lethal dose (50 percent kill): 3,882 mg/kg N/R TXAPA9 83,108,1986
intraperitoneal
rat 		lowest published toxic dose: 750 mg/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase 		VCVGK* -,47,1984
intraperitoneal
rat 		lowest published toxic dose: 785.1 mg/kg Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		BCPCA6 65,857,2003
oral
guinea pig 		lethal dose (50 percent kill): 1,700 mg/kg N/R 85GMAT -,28,1982
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 2,700 mg/kg N/R GTPZAB 32(10),25,1988
oral
mouse 		lethal dose (50 percent kill): 2,700 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity 		GTPZAB 13(9),56,1969
oral
rat 		lethal dose (50 percent kill): 2,383 mg/kg Eye: Chromodacryorrhea

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0571670
oral
rabbit 		lethal dose (50 percent kill): 3,300 mg/kg N/R 85GMAT -,28,1982
subcutaneous
mouse 		lethal dose (50 percent kill): 2 gm/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Other changes 		JJPAAZ 3,99,1954
unreported route
mouse 		lethal dose (50 percent kill): 2,700 mg/kg Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,47,1984
unreported route
rat 		lethal dose (50 percent kill): 3,200 mg/kg Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,47,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/4 hour/45 day- intermittent Blood: Luekopenia VCVGK* -,48,1994
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/4 hour/90 day- intermittent Brain and Coverings: Other degenerative changes VCVGK* -,48,1994
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/4 hour/122 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,48,1994
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/4 hour/122 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVGK* -,48,1994
intraperitoneal
mouse 		lowest published toxic dose: 3,768 mg/kg/18 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		JTEHD6 21,325,1987
unreported route
rat 		lowest published toxic dose: 16 mg/kg/5 day/4 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		VCVGK* -,48,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - HUNGARY time-weighted average 3 mg/m3, short term exposure limit 6 mg/m3, Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 3 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83863;
Number of Industries 5;
Total Number of Facilities 105;
Number of Occupations 9;
Total Number of Employees Exposed 18,936
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83863;
Number of Industries 2;
Total Number of Facilities 64;
Number of Occupations 3;
Total Number of Employees Exposed 1,891;
Total Number of Female Employees Exposed 238


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a chemical intermediate

NIOSH PROFILE (AROMATIC COMPOUNDS, BROMINATED), SRC, 10/77

RTECS Compound Description:
   Mutagen

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