The Registry of Toxic Effects of Chemical Substances

1,3 - Benzenedicarbonitrile

RTECS #: CZ1900000

CAS #: 626-17-5

UPDATE: November 2004 MW: 128.14 MF: C8H4N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,3 - Benzendikarbonitril (Czech)
  2. 1,3 - Dicyanobenzene
  3. Dinitrile of isophthalic acid
  4. IPN
  5. Isoftalodinitril (Czech)
  6. Isoftalonitril (Czech)
  1. Isophthalodinitrile
  2. Isophthalonitrile
  3. Nitril kyseliny isoftalove (Czech)
  4. m - Dicyanobenzene
  5. m - Phthalodinitrile
  6. m - Phthalodinitrile (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,905,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >8,970 mg/m3/1 hour N/R NTIS** OTS0533488
intraperitoneal
mouse 		lethal dose (50 percent kill): 450 mg/kg Behavioral: Convulsions or effect on seizure threshold ZAARAM 19,225,1969
intraperitoneal
rat 		lethal dose (50 percent kill): 520 mg/kg Eye: Ptosis

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Acute pulmonary edema 		APFRAD 48,23,1990
oral
cat 		lethal dose (50 percent kill): 500 mg/kg N/R ZAARAM 19,225,1969
oral
mouse 		lethal dose (50 percent kill): 178 mg/kg N/R JMCMAR 21,906,1978
oral
rat 		lethal dose (50 percent kill): 860 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease 		NTIS** OTS0533488
oral
rabbit 		lethal dose (50 percent kill): 250 mg/kg N/R ZAARAM 19,225,1969
skin
rat 		lethal dose (50 percent kill): >5 gm/kg N/R NTIS** OTS0533488
skin
rabbit 		lethal dose (50 percent kill): >2 gm/kg N/R NTIS** OTS0533488
unreported route
guinea pig 		lethal dose (50 percent kill): 370 mg/kg N/R GISAAA 39(11),17,1974
unreported route
mouse 		lethal dose (50 percent kill): 548 mg/kg N/R GISAAA 39(11),17,1974
unreported route
rat 		lethal dose (50 percent kill): 1,708 mg/kg N/R GISAAA 39(11),17,1974
unreported route
rabbit 		lethal dose (50 percent kill): 350 mg/kg N/R GISAAA 39(11),17,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,250 mg/m3/6 hour/2 week- intermittent Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0533488
oral
mouse 		lowest published toxic dose: 13,500 mg/kg/90 day- intermittent Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Related to Chronic Data: Changes in ovarian weight 		NTIS** OTS0572435
oral
mouse 		lowest published toxic dose: 5,250 mg/kg/35 day- continuous Liver: Other changes

Liver: Changes in liver weight 		NTIS** OTS0538085
oral
rat 		lowest published toxic dose: 5,250 mg/kg/1 week- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0533488
oral
rat 		lowest published toxic dose: 4,050 mg/kg/30 day- intermittent Behavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0533488
oral
rat 		lowest published toxic dose: 2,475 mg/kg/99 day- intermittent Liver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Urine volume increased 		NTIS** OTS0537740
oral
rabbit 		lowest published toxic dose: 4,550 mg/kg/26 week- intermittent Liver: Liver function tests impaired

Liver: Other changes

Blood: Pigmented or nucleated red blood cells 		GISAAA 39(11),17,1974


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, short term exposure limit 20 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO m-PHTHALODINITRILE-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3037;
Number of Industries 1;
Total Number of Facilities 4;
Number of Occupations 5;
Total Number of Employees Exposed 208;
Total Number of Female Employees Exposed 44


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate for synthetic fibers, agricultural chemicals, rubber chemicals
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75.

Used as intermediate for synthetic fibers, agricultural chemicals, rubber chemicals

RTECS Compound Description:
   Drug
   Primary Irritant

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