The Registry of Toxic Effects of Chemical Substances

1,2 - Benzenedicarboxylic acid, diisononyl ester

RTECS #: CZ3850000

CAS #: 28553-12-0

UPDATE: May 2005 MW: 418.68 MF: C26H42O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Baylectrol 4200
  2. Isononyl alcohol, phthalate (2:1)
  3. Jayflex DINP
  4. Diisononyl phthalate
  5. DINP
  6. DINP2
  7. DINP3
  8. ENJ 2065
  1. Palatinol N
  2. Palatinol DN
  3. Phthalic acid, diisononyl ester
  4. Phthalisocizer DINP
  5. Sansocizer DINP
  6. Vestinol NN
  7. Vinylcizer 90
  8. Witamol 150


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FCTOD7 35,501,1997
oral
rat 		lowest published toxic dose: 18 gm/kg (15-21 day pregnant/10 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 72,77,2003
oral
rat 		lowest published toxic dose: 11.25 gm/kg (7-21 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system REPTED 17,475,2003
oral
rat 		lowest published toxic dose: 17.4 gm/kg (7-22 day pregnant/1-13 day after birth) Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Other postnatal measures or effects 		REPTED 17,475,2003
oral
rat 		lowest published toxic dose: 10.2 gm/kg (7-22 day pregnant/1 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects REPTED 17,475,2003
oral
rat 		lowest published toxic dose: 400 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) REPTED 16,679,2002
oral
rat 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system 		REPTED 16,679,2002
oral
rat 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities 		REPTED 16,679,2002
oral
rat 		lowest published toxic dose: 8,250 mg/kg (14-21 day pregnant/3 day after birth) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Other developmental abnormalities 		REPTED 16,679,2002
oral
rat 		lowest published toxic dose: 11.3 gm/kg (7-21 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system REPTED 18,53,2004


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 201 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** OTS0556283-3


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 11,256 mg/kg/28 day- continuous Liver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOXID9 3,157,1983
oral
rat 		lowest published toxic dose: 109 gm/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia

Related to Chronic Data: Changes in uterine weight 		NTIS** OTS0530645


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
REPTED 16,679,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

RTECS Compound Description:
   Tumorigen
   Reproductive Effector

ALT CAS #: 41375-91-1
ALT CAS #: 105009-97-0
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