The Registry of Toxic Effects of Chemical Substances
Benzene, m - dichloro - RTECS #: CZ4499000
CAS #: 541-73-1
The Registry of Toxic Effects of Chemical Substances
Benzene, m - dichloro - |
| UPDATE: August 2004 | MW: 147.00 | MF: C6H4Cl2 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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micronucleus test
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intraperitoneal | mouse
175 mg/kg/24 hour
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MUTAEX 2,111,1987
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gene conversion and mitotic recombination
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Saccharomyes cerevisiae
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5 ppm
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NTIS** PB84-138973
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intraperitoneal | mouse
lethal dose (50 percent kill): 1,062 mg/kg
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N/R
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MUTAEX 2,111,1987
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oral | rat
lowest published toxic dose: 200 mg/kg
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Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
VCVGK* -,24,1984
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | rat
lowest published toxic dose: 1,470 mg/kg/10 day- intermittent
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Liver: Changes in liver weight | Nutritional and Gross Metabolic: Changes in: Ca Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
DCTODJ 18,201,1995
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oral | rat
lowest published toxic dose: 3,330 mg/kg/90 day- intermittent
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Endocrine: Other changes | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
DCTODJ 18,201,1995
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review
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Animal Inadequate Evidence
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IMEMDT 73,223,1999
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International Agency for Research on Cancer (IARC) Cancer Review
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Human Inadequate Evidence
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IMEMDT 73,223,1999
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International Agency for Research on Cancer (IARC) Cancer Review
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Group 3
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IMEMDT 73,223,1999
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TOXICOLOGY REVIEW
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TOLED5 127,111,2002
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: X2135 |
 ;Number of Industries 2; Total Number of Facilities 49; Number of Occupations 3; Total Number of Employees Exposed 418; Total Number of Female Employees Exposed 80 | |||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA Section 8(d) unpublished health/safety studies
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On EPA IRIS database
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
DCTODJ
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Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1-
1977/78-
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IMEMDT
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IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
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MUTAEX
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Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ,
UK) V.1- 1986-
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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TOLED5
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Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
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VCVGK*
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"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia".
(Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia,
1994.
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