The Registry of Toxic Effects of Chemical Substances

Benzene, o - dichloro -

RTECS #: CZ4500000

CAS #: 95-50-1

UPDATE: November 2004 MW: 147.00 MF: C6H4Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. NCI - C54944
  2. Special termite fluid
  3. Benzene, 1,2 - dichloro -
  4. Chloroben
  5. o - Dichlor benzol
  6. o - Dichlorbenzene
  7. o - Dichlorobenzene
  8. o - Dichlorobenzene (ACGIH:OSHA)
  1. 1,2 - Dichlorobenzene
  2. Dilatin DB
  3. Dizene
  4. Dowtherm E
  5. Orthodichlorobenzene
  6. Orthodichlorobenzol
  7. Termitkil


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/30S rinse mild AMIHAB 17,180,1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms mouse lymphocyte 6,500 µg/L (+enzymatic activation step) SCIEAS 236,933,1987
micronucleus test intraperitoneal
mouse 		187 mg/kg/24 hour MUTAEX 2,111,1987
gene conversion and mitotic recombination Saccharomyes cerevisiae 1 mmol/L MUREAV 413,205,1998
sister chromatid exchange hamster ovary 59 mg/L SCIEAS 236,933,1987
sperm morphology intraperitoneal
rat 		250 mg/kg JACTDZ 4(2),224,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 200 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FAATDF 5,190,1985
inhalation
rat 		lowest published toxic concentration: 500 ppm/6 hour (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** OTS0535228
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) JACTDZ 4(1),224,1985


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 30,900 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Adrenal cortex tumors 		NTIS** PB86-144888/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 800 ppm/24 hour Liver: Hepatitis (hepatocellular necrosis), diffuse JPBAA7 44,281,1937
inhalation
rat 		lowest published lethal concentration: 821 ppm/7 hour Behavioral: General anesthetic

Liver: Hepatitis (hepatocellular necrosis), zonal

Eye: Lacrimation 		AMIHAB 17,180,1958
inhalation
rat 		lethal concentration (50 percent kill): 8,150 mg/m3/4 hour Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: General anesthetic

Behavioral: Muscle contraction or spasticity 		VCVGK* -,24,1984
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,228 mg/kg N/R MUTAEX 2,111,1987
intraperitoneal
rat 		lethal dose (50 percent kill): 840 mg/kg N/R MEPAAX 20,519,1969
intraperitoneal
rat 		lowest published toxic dose: 735 mg/kg N/R VCVGK* -,24,1984
intraperitoneal
rat 		lowest published toxic dose: 1 mg/kg Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 111,69,1991
intraperitoneal
rat 		lowest published toxic dose: 735 mg/kg Gastrointestinal: Changes in structure or function of exocrine pancreas

Gastrointestinal: Other changes 		VCVGK* -,24,1984
intravenous
mouse 		lowest published lethal dose: 400 mg/kg N/R JPBAA7 44,281,1937
intravenous
rabbit 		lowest published lethal dose: 250 mg/kg N/R JPBAA7 44,281,1937
oral
guinea pig 		lowest published lethal dose: 2 gm/kg N/R 14CYAT 2,1336,1963
oral
mouse 		lethal dose (50 percent kill): 4,386 mg/kg N/R YKYUA6 32,471,1981
oral
rat 		lethal dose (50 percent kill): 500 mg/kg N/R WRPCA2 9,119,1970
oral
rabbit 		lethal dose (50 percent kill): 500 mg/kg N/R 85ARAE 3,32,1976/1977
subcutaneous
rat 		lethal dose (50 percent kill): 5 gm/kg N/R TSCAT* OTS 205976
skin
rabbit 		lethal dose (50 percent kill): >10 gm/kg N/R NTIS** OTS0521597


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 290 mg/m3/7 hour/26 week- intermittent Liver: Other changes VCVGK* -,24,1994
inhalation
rat 		lowest published toxic concentration: 200 mg/m3/4 hour/17 week- intermittent Brain and Coverings: Other degenerative changes

Blood: Changes in cell count (unspecified) 		VCVGK* -,24,1994
oral
mouse 		lowest published toxic dose: 7 gm/kg/14 day- intermittent Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-255,1985
oral
mouse 		lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight 		NTPTR* NTP-TR-255,1985
oral
rat 		lowest published toxic dose: 27,300 µg/kg/39 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Angranulocytosis

Blood: Changes in erythrocyte (RBC) count 		GISAAA 33(10),15,1968
oral
rat 		lowest published toxic dose: 3 gm/kg/10 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in leukocyte (WBC) count 		DCTODJ 14,83,1991
oral
rat 		lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count 		NTPTR* NTP-TR-255,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 50 ppm DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 7,231,1974
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 7,231,1974
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 29,213,1982
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 29,213,1982
International Agency for Research on Cancer (IARC) Cancer Review Animal No Cancer Evidence IMEMDT 73,223,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,223,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 73,223,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,249,1998
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 50 ppm (300 mg/m3) DTLVS* 3,76,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 50 ppm (300 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 50 ppm (300 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 50 ppm (300 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 50 ppm (300 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (300 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM short term exposure limit 50 ppm (301 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (300 mg/m3), short term exposure limit 75 ppm (450 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 50 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 50 ppm (300 mg/m3), Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 50 mg/m3, short term exposure limit 100 mg/m3, Skin, JAN1993
Occupational Exposure Limit - JAPAN short term exposure limit 25 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 122 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 20 mg/m3, MAC(CEILING) 300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 50 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN CEILING 50 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (300 mg/m3), KZG- week 100 ppm (600 mg/m3),JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 50 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 50 ppm (306 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 50 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 50 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-DICHLOROBENZENE-air ceiling concentration 50 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24003;
Number of Industries 83;
Total Number of Facilities 8,838;
Number of Occupations 69;
Total Number of Employees Exposed 72,149
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24003;
Number of Industries 59;
Total Number of Facilities 10,577;
Number of Occupations 59;
Total Number of Employees Exposed 92,246;
Total Number of Female Employees Exposed 12,686


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as an insecticide and pesticide, and an intermediate for agricultural chemicals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63
85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96, 1892-1968. For publisher information, see JPTLAS.
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as an insecticide and pesticide, and an intermediate for agricultural chemicals

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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