The Registry of Toxic Effects of Chemical Substances

Benzene, 2,6 - diisocyanato - 1 - methyl -

RTECS #: CZ6310000

CAS #: 91-08-7

UPDATE: May 2005 MW: 174.17 MF: C9H6N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Isocyanic acid, 2 - methyl - meta - phenylene ester
  2. 2 - Methyl - meta - phenylene diisocyanate
  3. 2 - Methyl - meta - phenylene isocyanate
  4. Toluene 2,6 - diisocyanate
  5. 2,6 - Toluene diisocyanate
  1. Tolylene 2,6 - diisocyanate
  2. meta - Tolylene diisocyanate
  3. 2,6 - Diisocyanato - 1 - methylbenzene
  4. 2,6 - Diisocyanatotoluene
  5. 2,6 - TDI


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 600 mg/L EMMUEG 13,133,1989
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) NTPTR* NTP-TR-251,1986
mutation in microorganisms Salmonella typhimurium 300 µg/plate (+enzymatic activation step) MUREAV 438,109,1999
morphological transform mouse fibroblast 20 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
sister chromatid exchange hamster ovary 300 mg/L EMMUEG 13,133,1989
specific locus test mouse lymphocyte 25 mg/L EMMUEG 17,196,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 50 ppb Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes 		ATXKA8 19,364,1962
oral
wild bird 		lethal dose (50 percent kill): 100 mg/kg N/R AECTCV 12,355,1983


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.005 ppm; short term exposure limit 0.02 ppm DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 39,287,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,865,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,287,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,865,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,865,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA MAK 0.01 ppm (0.07 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 0.005 ppm (0.035 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.01 ppm (0.07 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.005 ppm (0.035 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.035 mg/m3, MAC(short term exposure limit) 0.070 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.005 ppm (0.04 mg/m3), KZG- week 0.01 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.02 mg(NCO)/m3, short term exposure limit 0.07 mg(NCO)/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.04 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0788;
Number of Industries 14;
Total Number of Facilities 609;
Number of Occupations 18;
Total Number of Employees Exposed 15,830
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0788;
Number of Industries 12;
Total Number of Facilities 415;
Number of Occupations 22;
Total Number of Employees Exposed 2,872;
Total Number of Female Employees Exposed 284


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the production of POLYURETHANE flexible foams, coatings, and elastomers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isocyanates, monomeric, 5521
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #42


REFERENCES:

CODEN
REFERENCE
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

Used in the production of POLYURETHANE flexible foams, coatings, and elastomers

NIOSH PROFILE (ISOCYANATES, ORGANIC), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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