The Registry of Toxic Effects of Chemical Substances

Benzene, p - dimethoxy -

RTECS #: CZ6650000

CAS #: 150-78-7

UPDATE: February 2004 MW: 138.18 MF: C8H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Anisole, p - methoxy -
  2. p - Methoxyanisole
  3. Quinol dimethyl ether
  4. Benzene, 1,4 - dimethoxy -
  5. p - Dimethoxybenzene
  6. 1,4 - Dimethoxybenzene
  7. Dimethylether hydrochinonu (Czech)
  1. Dimethyl ether hydroquinone
  2. Dimethylhydroquinone
  3. Dimethylhydroquinone ether
  4. DMB
  5. Hydroquinone, dimethyl ether
  6. USAF uctl - 1791
  7. USAF AN - 9


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
guinea pig 		40%/24 hour moderate FCTXAV 16,715,1978
skin
rabbit 		6 gm/12 day- intermittent mild JIHTAB 31,79,1949
skin
rabbit 		500 mg/24 hour moderate FCTXAV 16,715,1978


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 100 mg/kg N/R NTIS** AD277-689
oral
mouse 		lethal dose (50 percent kill): 4 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity 		GTPZAB 4(2),30,1960
oral
mouse 		lethal dose (50 percent kill): 2,300 mg/kg Behavioral: Muscle contraction or spasticity

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,295,1994
oral
rat 		lethal dose (50 percent kill): 3,600 mg/kg N/R FCTXAV 16,715,1978
oral
rat 		lowest published toxic dose: 500 mg/kg Cardiac: EKG changes not diagnostic of above

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,295,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2701;
Number of Industries 31;
Total Number of Facilities 3,010;
Number of Occupations 27;
Total Number of Employees Exposed 24,385;
Total Number of Female Employees Exposed 5,739


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Drug
   Primary Irritant

Click Here for Additional Information about RTECS