The Registry of Toxic Effects of Chemical Substances

Benzene, 1 - chloro - 2,4 - dinitro -

RTECS #: CZ0525000

CAS #: 97-00-7

UPDATE: May 2005 MW: 202.56 MF: C6H3ClN2O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. CDNB
  2. 1 - Chlor - 2,4 - dinitrobenzene
  3. 1 - Chloor - 2,4 - dinitrobenzeen (Dutch)
  4. 1 - Chloro - 2,4 - dinitrobenzene
  5. 4 - Chloro - 1,3 - dinitrobenzene
  6. 6 - Chloro - 1,3 - dinitrobenzene
  7. 1 - Chloro - 2,4 - dinitrobenzol (German)
  1. 1 - Cloro - 2,4 - dinitrobenzene (Italian)
  2. 1,3 - Dinitro - 4 - chlorobenzene
  3. 2,4 - Dinitrochlorobenzene
  4. 2,4 - Dinitro - 1 - chlorobenzene
  5. Dinitrochlorobenzol
  6. DNCB


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 µg/24 hour severe 85JCAE -,600,1986
skin
human 		30 µg severe CODEDG 2,247,1976
skin
human 		0.3 %/24 hour ADVEA4 94,407,1976
skin
human 		0.3 %/48 hour ADVEA4 94,407,1976
skin
mouse 		0.3%/24 hour open irritation test mild FCTOD7 40,1713,2002
skin
rabbit 		100 µg/24 hour open irritation test mild AIHAAP 23,95,1962
skin
rabbit 		2 mg/24 hour severe 85JCAE -,600,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage intraperitoneal
mouse 		30 mg/kg MUREAV 116,239,1983
DNA damage rat liver 5 µmol/L MUREAV 131,215,1984
mutation in microorganisms Salmonella typhimurium 3 µg/plate (+enzymatic activation step) ARDEAC 121,348,1985
mutation in microorganisms Salmonella typhimurium 50 µg/plate (-enzymatic activation step) ADREDL 266,315,1979
mutation in microorganisms Salmonella typhimurium 25 µg/plate (+/-enzymatic activation step) MUREAV 520,119,2002
morphological transform hamster kidney 10 mg/L ARTODN 45,307,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 280 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Peritonitis

Blood: Methemoglobinemia- Carboxhemoglobinemia 		AGGHAR 17,217,1959
oral
rat 		lethal dose (50 percent kill): 640 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia AGGHAR 17,217,1959
skin
guinea pig 		lowest published toxic dose: 60 mg/kg Skin: After topical application: Cutaneous sensitization (experimental) ADSYAF 76,549,1957
skin
mouse 		lowest published toxic dose: 1 pph Blood: Other changes TOXID9 72,174,2003
skin
mouse 		lowest published toxic dose: 0.1 pph Skin: After topical application: Dermatitis, allergic TOXID9 72,175,2003
skin
rabbit 		lethal dose (50 percent kill): 130 mg/kg Skin: After topical application: Primary irritation AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 200 µg/m3/4 hour/17 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins 		GTPZAB 29(8),59,1985
oral
rat 		lowest published toxic dose: 2,340 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes 		GTPZAB 32(2),48,1988
skin
mouse 		lowest published toxic dose: 67.2 mg/kg/13 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement) 		JJATDK 20,221,2000
skin
mouse 		lowest published toxic dose: 2.5 mg/kg/5 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Tumorigenic: Cells (cultured) transformed 		JAPTO* 21,257,2001
skin
mouse 		lowest published toxic dose: 60 mg/kg/7 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Increase in humoral response 		JJATDK 22,397,2002
skin
mouse 		lowest published toxic dose: 0.6 pph/2 day- intermittent Blood: Other changes

Skin: After topical application: Cutaneous sensitization (experimental) 		TOXID9 72,101,2003
skin
mouse 		lowest published toxic dose: 15 mg/kg/3 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental)

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXAPA9 183,66,2002
skin
mouse 		lowest published toxic dose: 15 mg/kg/3 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXAPA9 184,46,2002
skin
mouse 		lowest published toxic dose: 6 mg/kg/3 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental) FCTOD7 40,1713,2002
skin
mouse 		lowest published toxic dose: 70 mg/kg/8 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental)

Immunological Including Allergic: Increase in cellular immune response 		FCTOD7 40,1881,2002
skin
mouse 		lowest published toxic dose: 6 mg/kg/3 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental)

Immunological Including Allergic: Increase in cellular immune response 		TXCYAC 190,259,2003
skin
mouse 		lowest published toxic dose: 40 mg/kg/3 day- intermittent Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		ETOPFR 14,61,2003
skin
mouse 		lowest published toxic dose: 15 mg/kg/3 day- intermittent Immunological Including Allergic: Increase in cellular immune response ETOPFR 17,95,2004
skin
rat 		lowest published toxic dose: 20.6 mg/kg/8 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental)

Immunological Including Allergic: Increase in cellular immune response 		FCTOD7 40,1881,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TOLED5 140-141,213,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83616;
Number of Industries 1;
Total Number of Facilities 174;
Number of Occupations 1;
Total Number of Employees Exposed 1,221
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83616;
Number of Industries 2;
Total Number of Facilities 82;
Number of Occupations 2;
Total Number of Employees Exposed 170;
Total Number of Female Employees Exposed 14


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a reagent for detection of NICOTINIC ACID, NICOTINAMIDE and other PYRIDINE compounds
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ADREDL Archives of Dermatological Research. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.253- 1975-
ADSYAF Archives of Dermatology and Syphilology. (Chicago, IL) V.1-62, 1920-50. For publisher information, see ARDEAC.
ADVEA4 Acta Dermato-Venereologica. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.1- 1920-
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a reagent for detection of NICOTINIC ACID, NICOTINAMIDE and other PYRIDINE compounds

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Human Data
   Primary Irritant

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