The Registry of Toxic Effects of Chemical Substances
Benzene, pentachloro - RTECS #: DA6640000
CAS #: 608-93-5
The Registry of Toxic Effects of Chemical Substances
Benzene, pentachloro - |
| UPDATE: August 2004 | MW: 250.32 | MF: C6HCl5 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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DNA damage
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oral | rat
1,500 ng/kg/30 week- intermittent
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JJTHEC 65,825,2002
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | rat
lowest published toxic dose: 2 gm/kg (6-15 day pregnant)
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Reproductive: Specific developmental abnormalities: Musculoskeletal system
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TXCYAC 5,117,1975
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oral | rat
lowest published toxic dose: 1,802 mg/kg (13 week male)
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Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
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NTIS** PB91-185983
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oral | rat
lowest published toxic dose: 2,000 mg/kg (6-15 day pregnant)
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Reproductive: Other effects to embryo or fetus | Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXCYAC 5,117,1975
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intraperitoneal | rat
lowest published toxic dose: 1 mg/kg
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Liver: Other changes | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TXAPA9 111,69,1991
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intraperitoneal | rat
lowest published toxic dose: 2 mg/kg
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Kidney, Ureter, and Bladder: Changes in kidney weight
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TXAPA9 111,69,1991
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oral | mouse
lethal dose (50 percent kill): 1,175 mg/kg
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Behavioral: General anesthetic | Behavioral: Tremor
JEPTDQ 4(5-6),183,1980
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oral | rat
lethal dose (50 percent kill): 1,080 mg/kg
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Behavioral: General anesthetic | Behavioral: Tremor
JEPTDQ 4(5-6),183,1980
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skin | rat
lethal dose (50 percent kill): >2,500 mg/kg
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N/R
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JEPTDQ 4(5-6),183,1980
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | mouse
lowest published toxic dose: 5,940 mg/kg/15 day- continuous
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Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change | Behavioral: Tremor Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NIH-91-3125
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oral | mouse
lowest published toxic dose: 10,909 mg/kg/13 week- continuous
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Liver: Changes in liver weight | Kidney, Ureter, and Bladder: Changes in bladder weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
NTPTR* NIH-91-3125
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oral | rat
lowest published toxic dose: 1,662 mg/kg/28 day- continuous
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Liver: Changes in liver weight
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JTEHD6 11,663,1983
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oral | rat
lowest published toxic dose: 248 mg/kg/15 day- continuous
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Liver: Changes in liver weight | Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-91-3125
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oral | rat
lowest published toxic dose: 9 gm/kg/26 week- continuous
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Liver: Changes in liver weight | Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in leukocyte (WBC) count
JEPTDQ 4(5-6),183,1980
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oral | rat
lowest published toxic dose: 1,738 mg/kg/13 week- continuous
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Kidney, Ureter, and Bladder: Other changes in urine composition | Endocrine: Adrenal cortex hyperplasia Blood: Other changes
TXAPA9 119,181,1993
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oral | rat
lowest published toxic dose: 1,500 ng/kg/30 week- intermittent
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Brain and Coverings: Other degenerative changes
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JJTHEC 65,825,2002
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oral | rat
lowest published toxic dose: 4,500 ng/kg/30 week- intermittent
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Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
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JJTHEC 65,825,2002
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
TOXICOLOGY REVIEW
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TOLED5 127,101,2002
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
N/R
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N/R
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N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
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FEREAC 47,26992,82
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Used as a fungicide and to protect wood from fungal rots and wood-boring insects
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EPA TSCA Section 8(d) unpublished health/safety studies
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On EPA IRIS database
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NIOSH Analytical Method, 1994: Polychlorobenzenes, 5517
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NTP Toxicity studies, RPT# TOX-06, October 2000
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REFERENCES:
CODEN
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REFERENCE
FEREAC
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Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
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JEPTDQ
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Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3),
1977-81(?). For publisher information, see JEPOEC.
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JJTHEC
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Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya,
Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
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JTEHD6
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Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW,
Washington, DC 20005) V.1- 1975/76-
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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NTPTR*
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National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709)
No.206-
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TOLED5
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Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
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TXAPA9
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Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
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TXCYAC
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Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
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