The Registry of Toxic Effects of Chemical Substances

Benzenesulfonic acid, 5 - chloro - 2 - ( (2 - hydroxy - 1 - naphthalenyl) azo) - 4 - methyl - , barium salt

RTECS #: DB5500000

CAS #: 5160-02-1

UPDATE: November 2004 MW: 444.49 MF: C17H12ClN2O4S•1/2Ba


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - (4 - Chloro - o - sulfo - 5 - tolylazo) - 2 - naphthol, barium salt
  2. 1 - (4 - Chloro - o - sulpho - 5 - tolylazo) - 2 - naphthol, barium salt
  3. 1860 Red
  4. 5 - Chloro - 2 - ( (2 - hydroxy - 1 - naphthalenyl) azo) - 4 - methylbenzenesulfonic acid, barium salt (2:1)
  5. 5 - Chloro - 2 - ( (2 - hydroxy - 1 - naphthalenyl) azo) - 4 - methylbenzenesulphonic acid, barium salt
  6. 5 - Chloro - 2 - ( (2 - hydroxy - 1 - naphthyl) azo) - p - toluenesulfonic acid, barium salt
  7. Astro Orange
  8. Atomic Red
  9. Brilliant Red
  10. Brilliant Scarlet CA
  11. Segnale Red LCL
  12. Sico Lake Red 2L
  13. Superol Red C RT - 265
  14. Symuler Lake Red C
  15. Termosolido Red LCG
  16. Texan Red Toner D
  17. Toner Lake Red C
  18. Transparent Bronze Scarlet
  19. Vulcafix Scarlet R
  20. Vulcafix Scarlet R - D masse
  21. Brilliant Scarlet CBA
  22. Vulcafor Red 2R
  23. Vulcan Red LC
  24. Vulcol Fast Red L
  25. Wayne Red X - 2486
  26. Brilliant Scarlet CTA
  27. Brilliant Toner Z
  28. Bronze Red 16913 Yellowish
  29. Bronze Red RO
  30. Bronze Scarlet
  31. Bronze Scarlet C
  32. Bronze Scarlet CA
  33. Bronze Scarlet CBA
  34. Bronze Scarlet CT
  35. Bronze Scarlet CTA
  36. Bronze Scarlet Toner
  37. C.I. 15585:1
  38. C.I. Pigment Red 53, barium salt
  39. C.I. Pigment Red 53:1
  40. Carnation Red
  41. Cosmetic Coral Red KO Bluish
  42. Cosmetic DVR
  43. Cosmetic Pigment Yellow Red DVR
  44. D & C Red No. 9
  45. D and C Red No. 9
  46. Dainichi Lake Red C
  47. Desert Red
  48. Duplex Red Lake C20 - 5925
  49. Eljon Lake Red C
  50. Hamilton Red
  51. Helio Red Toner LCLL
  52. Irgalite Red CBN
  53. Irgalite Red CBR
  54. Irgalite Red CBT
  55. Irgalite Red MBC
  56. Isol Lake Red LCS 12527
  57. Isol Red LCR 2517
  1. Lake Red 1520
  2. Lake Red C
  3. Lake Red C 18287
  4. Lake Red C 21245
  5. Lake Red C 27200
  6. Lake Red C 27217
  7. Lake Red C 27218
  8. Lake Red C Barium Toner
  9. Lake Red C Toner 8195
  10. Lake Red C Toner 8366
  11. Lake Red CC
  12. Lake Red CCT
  13. Lake Red CR
  14. Lake Red CRLC - 232 (barium)
  15. Lake Red GB barium salt
  16. Lake Red RRG
  17. Lake Red Toner C
  18. Lake Red Toner LCLL
  19. Latexol Scarlet R
  20. Latexol Scarlet R Solupowder
  21. Ld Rubber Red 16913
  22. Lutetia Red CLN
  23. Lutetia Red CLN - ST
  24. Microtex Lake Red CR
  25. Mohican Red A - 8008
  26. NCI - C53792
  27. No.3 Conc. Bronze Scarlet
  28. No.3 Conc. Scarlet
  29. Paridine Red LCL
  30. Pigment Lake Red BFC
  31. Pigment Lake Red CD
  32. Pigment Lake Red LC
  33. Pigment Red 53:1
  34. Pigment Red CD
  35. Potomac Red
  36. Recolite Red Lake C
  37. Recolite Red Lake CR
  38. Red 16913H
  39. Red 1860
  40. Red For Lake C
  41. Red For Lake C Toner RA - 5190
  42. Red For Lake Toner RA - 5190
  43. Red Lake C
  44. Red Lake C Toner
  45. Red Lake C Toner 20 - 5650
  46. Red Lake C Toner RA - 5190
  47. Red Lake CM 20 - 5650
  48. Red Lake CR - 1
  49. Red Lake R - 91
  50. Red Scarlet
  51. Red Toner Z
  52. Rubber Red 16913R
  53. Sanyo Lake Red C
  54. Scarlet Toner Y
  55. Segnale Red LC
  56. Segnale Red LCG


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) SCIEAS 236,933,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 130 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors 		NTPTR* NTP-TR-225,1982
oral
rat 		toxic dose : 109 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Blood: Tumors 		FCTOD7 25,619,1987
oral
rat 		lowest published toxic dose: 16,380 mg/kg/13 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Blood: Changes in spleen

Blood: Other changes 		NTIS** PB82-229592
oral
rat 		lowest published toxic dose: 27,300 mg/kg/13 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Blood: Changes in spleen

Blood: Other changes 		NTIS** PB82-229592
oral
rat 		lowest published toxic dose: 129,780 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors 		NTIS** PB82-229592
oral
rat 		lowest published toxic dose: 108,150 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB82-229592


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 21 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-225,1982
oral
mouse 		lowest published toxic dose: 87,600 mg/kg/2 year- continuous Blood: Changes in erythrocyte (RBC) count NTIS** OTS0543935
oral
rat 		lowest published toxic dose: 27,300 mg/kg/91 day- continuous Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-225,1982
oral
rat 		lowest published toxic dose: 546 gm/kg/2 year- continuous Endocrine: Changes in spleen weight TXAPA9 4,200,1962
oral
rat 		lowest published toxic dose: 43,260 mg/kg/103 week- continuous Blood: Leukemia

Reproductive: Tumorigenic effects: Testicular tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB82-229592
oral
rat 		lowest published toxic dose: 36,050 mg/kg/103 week- continuous Blood: Leukemia

Tumorigenic: Active as anti-cancer agent 		NTIS** PB82-229592


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 57,203,1993
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 8,107,1975
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 8,107,1975
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 57,203,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 57,203,1993
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg(Ba)/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3849;
Number of Industries 15;
Total Number of Facilities 1,160;
Number of Occupations 21;
Total Number of Employees Exposed 14,370
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3849;
Number of Industries 43;
Total Number of Facilities 8,245;
Number of Occupations 49;
Total Number of Employees Exposed 122,313;
Total Number of Female Employees Exposed 23,095


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of its alkaline earth metal salts, in cosmetics and in drugs
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis Bioassay (feed);clear evidence:rat NTPTR* NTP-TR-225,1982
NCI Carcinogenesis Studies (feed);equivocal evidence:rat
NTP Carcinogenesis Bioassay (feed);no evidence:mouse NTPTR* NTP-TR-225,1982


REFERENCES:

CODEN
REFERENCE
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in the manufacture of its alkaline earth metal salts, in cosmetics and in drugs

RTECS Compound Description:
   Tumorigen
   Mutagen

ALT CAS #: 12237-52-4
ALT CAS #: 12238-39-0
ALT CAS #: 12238-41-4
ALT CAS #: 12238-43-6
ALT CAS #: 24777-23-9
ALT CAS #: 52627-68-6
ALT CAS #: 68894-03-1
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