The Registry of Toxic Effects of Chemical Substances

1,2,4,5 Benzenetetracarboxylic 1,2:4,5 dianhydride

RTECS #: DB9300000

CAS #: 89-32-7

UPDATE: September 2000 MW: 218.12 MF: C10H2O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1H,3H - Benzo (1,2 - c:4,5 - c') difuran - 1,3,5,7 - tetrone
  2. Pyromellitic acid anhydride
  3. Pyromellitic acid dianhydride
  1. Pyromellitic anhydride
  2. Pyromellitic dianhydride
  3. Pyromellitic 1,2:4,5 - dianhydride (6CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 mg severe TPKVAL 14,125,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 150 mg/m3/4 hour N/R 85GMAT -,105,1982
oral
guinea pig 		lethal dose (50 percent kill): 1,595 mg/kg Behavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 51(11),79,1986
oral
mouse 		lethal dose (50 percent kill): 2,400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness 		TPKVAL 14,125,1975
oral
rat 		lethal dose (50 percent kill): 2,250 mg/kg Behavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 51(11),79,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/17 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression

Liver: Fatty liver degeneration 		TPKVAL 14,125,1975
oral
rat 		lowest published toxic dose: 1,320 mg/kg/30 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		GISAAA 51(11),79,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84105;
Number of Industries 6;
Total Number of Facilities 62;
Number of Occupations 9;
Total Number of Employees Exposed 721
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84105;
Number of Industries 4;
Total Number of Facilities 64;
Number of Occupations 3;
Total Number of Employees Exposed 1,926;
Total Number of Female Employees Exposed 728


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

NIOSH PROFILE (ORGANIC ANHYDRIDES), SRC, 2/82

RTECS Compound Description:
   Primary Irritant

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