The Registry of Toxic Effects of Chemical Substances

Benzene, 1,2,4,5 - tetrachloro -

RTECS #: DB9450000

CAS #: 95-94-3

UPDATE: November 2003 MW: 215.88 MF: C6H2Cl4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. Benzene tetrachloride
  2. RCRA waste number U207
  3. 1,2,4,5 - Tetrachlorbenzol (Russian)
  1. s - Tetrachlorobenzene
  2. 1,2,4,5 - Tetrachlorobenzene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose : >500 mg/kg N/R CBCCT* 4,107,1952
intraperitoneal
rat 		lowest published toxic dose: 0.8 mg/kg Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 111,69,1991
intraperitoneal
rat 		lowest published toxic dose: 0.5 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TXAPA9 111,69,1991
oral
mouse 		lethal dose (50 percent kill): 1,035 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		HYSAAV 30(1-3),8,1965
oral
rat 		lethal dose (50 percent kill): 1,500 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		HYSAAV 30(1-3),8,1965
oral
rat 		lethal dose (50 percent kill): 1,727 mg/kg Behavioral: Muscle weakness

Behavioral: Coma

Nutritional and Gross Metabolic: Body temperature decrease 		VCVGK* -,28,1984
oral
rabbit 		lethal dose (50 percent kill): 1,500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness 		GISAAA 30(1),9,1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 2,100 mg/kg/14 day- continuous Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NIH-91-3126
oral
mouse 		lowest published toxic dose: 4,550 mg/kg/13 week- continuous Liver: Changes in liver weight

Blood: Microcytosis with or without anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		NTPTR* NIH-91-3126
oral
mouse 		lowest published toxic dose: 4.536 mg/kg/105 day- continuous Liver: Changes in liver weight NTIS** PB92-128388
oral
mouse 		lowest published toxic dose: 4.725 mg/kg/105 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** PB92-128388
oral
rat 		lowest published toxic dose: 5,460 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Pigmented or nucleated red blood cells 		NTIS** PB91-185330
oral
rat 		lowest published toxic dose: 896 mg/kg/28 day- continuous Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		JTEHD6 11,663,1983
oral
rat 		lowest published toxic dose: 2,700 mg/kg/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		DCTODJ 7,113,1984
oral
rat 		lowest published toxic dose: 4,567 mg/kg/9 week- intermittent Endocrine: Changes in adrenal weight

Blood: Changes in bone marrow not included in above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 30(1),9,1965
oral
rat 		lowest published toxic dose: 12 mg/kg/35 week- intermittent Behavioral: Alteration of classical conditioning

Liver: Changes in liver weight 		GISAAA 30(1),9,1965
oral
rat 		lowest published toxic dose: 5,600 mg/kg/28 day- intermittent Behavioral: Muscle weakness

Behavioral: Coma

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,29,1994
oral
rabbit 		lowest published toxic dose: 12 mg/kg/35 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in other cell count (unspecified) 		GISAAA 30(1),9,1965
unreported route
rat 		lowest published toxic dose: 575 mg/kg/60 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,29,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polychlorobenzenes, 5517
NTP Toxicity studies, RPT# TOX-07, October 2000


REFERENCES:

CODEN
REFERENCE
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Tumorigen

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