The Registry of Toxic Effects of Chemical Substances

Benzene, 1,3,5 - trichloro -

RTECS #: DC2100100

CAS #: 108-70-3

UPDATE: July 2000 MW: 181.44 MF: C6H3Cl3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. s - Trichlorobenzene
  2. sym - Trichlorobenzene
  1. 1,3,5 - Trichlorobenzene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg mild NTIS** OTS0537049
skin
rabbit 		500 mg/24 hour mild NTIS** OTS0537049


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
dominant lethal test parenteral
other insects 		10 ppm EVETBX 2,1029,1973
dominant lethal test skin
other insects 		10 ppm EVETBX 2,1029,1973
micronucleus test intraperitoneal
mouse 		425 mg/kg/24 hour MUTAEX 2,111,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >9,300 mg/m3/1 hour N/R NTIS** OTS0537049
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,260 mg/kg N/R MUTAEX 2,111,1987
oral
mouse 		lethal dose (50 percent kill): 3,350 mg/kg N/R NTIS** UCRL-13701
oral
rat 		lethal dose (50 percent kill): 800 mg/kg N/R 48RKAL -,389,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 7,380 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight 		DCTODJ 11,11,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (40 mg/m3), JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2497;
Number of Industries 3;
Total Number of Facilities 60;
Number of Occupations 8;
Total Number of Employees Exposed 1,673


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as an industrial chemical, chemical intermediate, solvent and emulsifier
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
48RKAL "Industrial and Environmental Xenobiotics: Metabolism and Pharmacokinetics of Organic Chemicals and Metals, Proceedings of an International Conference, Prague, 1980," Gut, I., et al., Berlin, Fed. Rep, Ger., Springer-Verlag, 1981
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
EVETBX Environmental Entomology. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as an industrial chemical, chemical intermediate, solvent and emulsifier

RTECS Compound Description:
   Mutagen
   Primary Irritant

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