The Registry of Toxic Effects of Chemical Substances

Benzene, trimethyl - (mixed isomers)

RTECS #: DC3220000

CAS #: 25551-13-7

UPDATE: November 2004 MW: 120.21 MF: C9H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Methylxylene
  2. Trimethyl benzene (ACGIH:OSHA)
  1. Trimethyl benzene (mixed isomers)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 28ZPAK -,24,1972
skin
rabbit 		500 mg/24 hour moderate 28ZPAK -,24,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 8,970 mg/kg N/R 28ZPAK -,24,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (120 mg/m3) DTLVS* 3,269,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (120 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (120 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (125 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (123 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (120 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (120 mg/m3), short term exposure limit 40 ppm (200 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 100 mg/m3, 2003
Occupational Exposure Limit - SWEDEN NGV 25 ppm (120 mg/m3), KTV 35 ppm (170 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 25 ppm (125 mg/m3), short term exposure limit 35 ppm, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 25 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 25 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIMETHYL BENZENE-air 10 hour time-weighted average 25 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1303;
Number of Industries 2;
Total Number of Facilities 198;
Number of Occupations 2;
Total Number of Employees Exposed 790;
Total Number of Female Employees Exposed 365


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

NIOSH PROFILE (ARENES), SRI, 2/77

RTECS Compound Description:
   Primary Irritant

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