The Registry of Toxic Effects of Chemical Substances

Benzene, 1,2,4 - trimethyl -

RTECS #: DC3325000

CAS #: 95-63-6

UPDATE: November 2004 MW: 120.21 MF: C9H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,2,4 - Trimethylbenzene
  2. Asymmetrical trimethylbenzene
  3. Benzene, 1,2,5 - trimethyl -
  4. Pseudocumene
  1. Pseudocumol
  2. as - Trimethylbenzene
  3. psi - Cumene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange intraperitoneal
mouse 		900 mg/kg MUREAV 412,299,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 18,000 mg/m3/4 hour N/R VCVGH* -,175,1990
intraperitoneal
guinea pig 		lowest published lethal dose: 1,788 mg/kg N/R AMIHBC 9,227,1954
intraperitoneal
guinea pig 		lowest published lethal dose: 1.5 mL/kg N/R VCVGH* -,176,1990
intraperitoneal
rat 		lowest published lethal dose: 1,752 mg/kg N/R 85KYAH 11,1258,1989
intraperitoneal
rat 		lethal dose (30 percent kill): 5 mL/kg Lung, Thorax, or Respiration: Other changes

Vascular: Regional or general arteriolar or venous dilation 		VCVGH* -,176,1990
oral
mouse 		lethal dose (50 percent kill): 6,900 mg/kg N/R VCVGH* -,175,1990
oral
rat 		lethal dose (50 percent kill): 5 gm/kg N/R 85JCAE -,34,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/24 hour/17 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		GISAAA 44(5),15,1979
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour/20 day- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Analgesia

Behavioral: Alteration of operant conditioning 		NRTXDN 22,79,2001
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/16 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition VCVGH* -,176,1990
oral
rat 		lowest published toxic dose: 10 gm/kg/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TIHEEC 1(3),67,1985
oral
rat 		lowest published toxic dose: 6,400 mg/kg/8 week- intermittent Peripheral Nerve and Sensation: Recording from afferent nerve

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JJATDK 13,123,1993
oral
rat 		lowest published toxic dose: 19,600 mg/kg/4 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGH* -,176,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (120 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 25 ppm (120 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (125 mg/m3), SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 100 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: B0044;
Number of Industries 2;
Total Number of Facilities 33;
Number of Occupations 13;
Total Number of Employees Exposed 3,186
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: B0044;
Number of Industries 47;
Total Number of Facilities 3,684;
Number of Occupations 42;
Total Number of Employees Exposed 65,953;
Total Number of Female Employees Exposed 9,768


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in production of TRIMELLITIC ANHYDRIDE and as a dye carrier
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8911
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in production of TRIMELLITIC ANHYDRIDE and as a dye carrier

NIOSH PROFILE (ARENES), SRI, 2/77

NIOSH PROFILE (TRIMETHYL BENZENES), SRC, 1/81

RTECS Compound Description:
   Mutagen

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