The Registry of Toxic Effects of Chemical Substances

Benzhydrol, 4,4' - dichloro - alpha - (trichloromethyl) -

RTECS #: DC8400000

CAS #: 115-32-2

UPDATE: November 2004 MW: 370.48 MF: C14H9Cl5O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,1,1 - Trichlor - 2,2 - bis (4 - chlorphenyl) - aethanol (German)
  2. 1,1 - Bis (4 - chlorophenyl) - 2,2,2 - trichloroethanol
  3. 1,1 - Bis (chlorophenyl) - 2,2,2 - trichloroethanol
  4. 1,1 - Bis (p - chlorophenyl) - 2,2,2 - trichloroethanol
  5. 2,2,2 - Trichloor - 1,1 - bis (4 - chloor fenyl) - ethanol (Dutch)
  6. 2,2,2 - Trichlor - 1,1 - bis (4 - chlor - phenyl) - aethanol (German)
  7. 2,2,2 - Trichloro - 1,1 - bis (4 - chlorophenyl) - ethanol (French)
  8. 2,2,2 - Trichloro - 1,1 - bis (4 - cloro - fenil) - etanolo (Italian)
  9. 2,2,2 - Trichloro - 1,1 - di - (4 - chlorophenyl) ethanol
  10. 4,4' - Dichloro - alpha - (trichloromethyl) benzhydrol
  11. 4 - Chloro - alpha - (4 - chlorophenyl) - alpha - (trichloromethyl) benzenemethanol
  12. Acarin
  13. Benzenemethanol, 4 - chloro - alpha - (4 - chlorophenyl) - alpha - (trichloromethyl) -
  14. CPCA
  15. Carbax
  16. Cekudifol
  17. DTMC
  18. Decofol
  19. Di - (p - chlorophenyl) trichloromethylcarbinol
  1. Dichlorokelthane
  2. Dicofol
  3. Dicofol technical grade
  4. Dicomite
  5. ENT 23,648
  6. Ethanol, 2,2,2 - trichloro - 1,1 - bis (p - chlorophenyl) -
  7. FW 293
  8. Hifol
  9. Hilfol 18.5 EC
  10. Keltane
  11. Kelthane
  12. Kelthane A
  13. Kelthane dust base
  14. Kelthanethanol
  15. Milbol
  16. Mitigan
  17. NCI - C00486
  18. para,para' - Kelthane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human leukocyte 20 mg/L HOEKAN 29,33,1979
micronucleus test oral
mouse 		215 mg/kg CHYCDW 21,238,1987
morphological transform oral
rat 		4,620 mg/kg/77 day- continuous CRNGDP 11,1413,1990
sister chromatid exchange human lymphocyte 1 µmol/L ARTODN 52,221,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 430 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		CHYCDW 21,238,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 17 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NCITR* NCI-TR-90,1978
oral
mouse 		toxic dose : 35 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NCITR* NCI-TR-90,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >5 gm/m3/4 hour N/R PEMNDP 9,267,1991
intraperitoneal
rat 		lethal dose (50 percent kill): 1,150 mg/kg N/R TXAPA9 15,30,1969
oral
chicken 		lethal dose (50 percent kill): 4,365 mg/kg N/R VETNAL 60(10),64,1984
oral
dog 		lethal dose (50 percent kill): 4 gm/kg N/R VTYMAC 74,1119,1979
oral
guinea pig 		lethal dose (50 percent kill): 1,810 mg/kg N/R VCVGK* -,191,1994
oral
mouse 		lethal dose (50 percent kill): 420 mg/kg N/R VCVGK* -,191,1994
oral
rat 		lethal dose (50 percent kill): 575 mg/kg N/R VCVGK* -,191,1994
oral
rabbit 		lethal dose (50 percent kill): 1,810 mg/kg Behavioral: Muscle contraction or spasticity TXAPA9 1,119,1959
oral
rabbit 		lethal dose (50 percent kill): 575 mg/kg N/R HBPTO* 2,1342,2001
oral
woman 		lowest published toxic dose: 800 µL/kg Eye: Miosis (pupilliary constriction)

Behavioral: Excitement

Gastrointestinal: Hypermotility, diarrhea 		YAKUD5 34,1232,1992
skin
rat 		lethal dose (50 percent kill): 100 mg/kg N/R VCVGK* -,191,1994
skin
rabbit 		lethal dose (50 percent kill): 1,870 mg/kg N/R VCVGK* -,191,1994
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 433 mg/kg N/R GISAAA 38(8),101,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
chicken 		lowest published toxic dose: 8,368 mg/kg/20 day- intermittent Behavioral: Somnolence (general depressed activity)

Liver: Liver function tests impaired

Endocrine: Hyperglycemia 		VETNAL 60(10),64,1984
oral
dog 		lowest published toxic dose: 8,212.5 mg/kg/1 year- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field HBPTO* 2,1342,2001
oral
mouse 		lowest published toxic dose: 8,190 mg/kg/13 week- continuous Cardiac: Changes in heart weight

Liver: Other changes

Liver: Changes in liver weight 		ESKHA5 105,42,1987
oral
rat 		lowest published toxic dose: 4,200 mg/kg/12 week- continuous Liver: Other changes

Liver: Changes in liver weight

Endocrine: Changes in thyroid weight 		TXCYAC 1,113,1973
oral
rat 		lowest published toxic dose: 2,670 mg/kg/25 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 39(10),102,1974
oral
rat 		lowest published toxic dose: 6,000 mg/kg/30 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct BECTA6 69,741,2002
oral
rat 		lowest published toxic dose: 12,000 mg/kg/30 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		BECTA6 69,741,2002
oral
rat 		lowest published toxic dose: 15,000 mg/kg/30 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight 		BECTA6 69,741,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 30,87,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,87,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
RREVAH 56,107,1975
TOXICOLOGY REVIEW
TOLED5 128,45,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,112,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83793;
Number of Industries 3;
Total Number of Facilities 646;
Number of Occupations 2;
Total Number of Employees Exposed 9,769
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83793;
Number of Industries 2;
Total Number of Facilities 474;
Number of Occupations 1;
Total Number of Employees Exposed 3,934;
Total Number of Female Employees Exposed 365


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse NCITR* NCI-TR-90,1978
NCI Carcinogenesis Bioassay (feed);no evidence:rat NCITR* NCI-TR-90,1978


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HOEKAN Hokkaidoritsu Eisei Kenkyushoho. Report of the Hokkaido Institute of Public Health. (Nishi- 12-chome, Kita-19-jo, Kita-ku, Sapporo 060, Japan) No.1- 1951-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924-
VTYMAC VM/SAC, Veterinary Medicine and Small Animal Clinician. (Veterinary Medicine Publishing Co., 690 S. 4th St., POB 13265, Edwardsville, KS 66113) V.59- 1964-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as acaricide (miticide) in agricultural and nonagricultural applications

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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