The Registry of Toxic Effects of Chemical Substances

Benzidine, 3,3' - dimethoxy -

RTECS #: DD0875000

CAS #: 119-90-4

UPDATE: May 2005 MW: 244.32 MF: C14H16N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 3,3' - Dianisidine
  2. 3,3' - Dimethoxybenzidin (Czech)
  3. 3,3' - Dimethoxybenzidine
  4. 3,3' - Dimetossibenzodina (Italian)
  5. 4,4' - Diamino - 3,3' - dimethoxybiphenyl
  6. Acetamine Diazo Black RD
  7. Acetamine Diazo Navy RD
  8. Amacel Developed Navy SD
  9. Azoene Fast Blue Base
  10. Azogene Fast Blue B
  11. Blue BN Base
  12. Blue Base NB
  13. Blue Base irga B
  14. Brentamine Fast Blue B Base
  15. C.I. 24110
  16. C.I. Azoic Diazo Component 48
  17. C.I. Disperse Black 6
  18. Cellitazol B
  19. Cibacete Diazo Navy Blue 2B
  20. DMB
  1. Diacel Navy DC
  2. Diacelliton Fast Grey G
  3. Dianisidine
  4. Diato Blue Base B
  5. Diazo Fast Blue B
  6. Fast Blue B Base
  7. Fast Blue DSC Base
  8. Hiltonil Fast Blue B Base
  9. Kayaku Blue B Base
  10. Lake Blue B Base
  11. Meisei Teryl Diazo Blue HR
  12. Mitsui Blue B Base
  13. Naphthanil Blue B Base
  14. RCRA waste number U091
  15. Setacyl Diazo Navy R
  16. Spectrolene Blue B
  17. o,o' - Dianisidine
  18. o - Dianisidin (Czech, German)
  19. o - Dianisidina (Italian)
  20. o - Dianisidine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intraperitoneal
mouse 		100 mg/kg MUREAV 319,19,1993
DNA adduct dog other cell types 100 µmol/L CNREA8 44,1893,1984
DNA damage human liver 100 µmol/L TOSCF2 53,71,2000
DNA damage human other cell types 100 µmol/L TOSCF2 53,71,2000
DNA damage human lymphocyte 200 µmol/L/2 hour TOSCF2 72,283,2003
DNA damage oral
mouse 		600 mg/kg MUREAV 440,1,1999
DNA damage rat liver 56 µmol/L TOSCF2 53,71,2000
DNA damage oral
rat 		960 mg/kg TOSCF2 53,71,2000
unscheduled DNA synthesis human HeLa cell 100 nmol/L CNREA8 38,2621,1978
unscheduled DNA synthesis rat liver 500 µmol/L ENMUDM 3,11,1981
mutation in microorganisms Salmonella typhimurium 1 µg/plate (-enzymatic activation step) IGAYAY 123,18,1982
mutation in microorganisms Salmonella typhimurium 3 µg/plate (+enzymatic activation step) TOSCF2 56,351,2000
micronucleus test rat liver 180 µmol/L TOSCF2 53,71,2000
morphological transform hamster kidney 80 µg/L BJCAAI 37,873,1978
other mutation test systems dog other cell types 100 µmol/L CNREA8 44,1893,1984
other mutation test systems intraperitoneal
mouse 		100 mg/kg MUREAV 319,19,1993
phage inhibition capacity Escherichia coli 100 mmol/L MDMIAZ 31,11,1979
sister chromatid exchange hamster ovary 500 µg/L ENMUDM 7,1,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
hamster 		lowest published toxic dose: 588 gm/kg/70 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		PAACA3 10,78,1969
oral
rat 		lowest published toxic dose: 12 gm/kg/56 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Ear: Tumors

Skin and Appendages: Tumors 		GTPZAB 9(7),18,1965


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published lethal dose: 600 mg/kg N/R AEXPBL 58,167,1907
oral
rat 		lethal dose (50 percent kill): 1,920 mg/kg N/R 85JCAE -,723,1986
oral
rat 		lowest published toxic dose: 960 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		TOSCF2 53,71,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 4,41,1974
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,198,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,198,1987
TOXICOLOGY REVIEW
AEHLAU 23,6,1971
TOXICOLOGY REVIEW
ADCSAJ 13,271,1970


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE Carcinogen, JAN1993
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - SWEDEN Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM Carcinogen, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-DIANISIDINE-BASED DYES-air Carcinogen lowest feasible conc. NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80274;
Number of Industries 2;
Total Number of Facilities 49;
Number of Occupations 3;
Total Number of Employees Exposed 122
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80274;
Number of Industries 4;
Total Number of Facilities 92;
Number of Occupations 11;
Total Number of Employees Exposed 2,481;
Total Number of Female Employees Exposed 866


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in the production of dyes
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #ID-71


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IGAYAY Igaku No Ayumi. Progress in Medicine. (Ishiyaku Shuppan K.K., 1-7-10, Honkomagom, Bunkyo-ku, Tokyo, Japan) V.1- 1946-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

Used as an intermediate in the production of dyes

NIOSH PROFILE (o-DIANISIDINE), TIRC, 4/80

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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