The Registry of Toxic Effects of Chemical Substances

Benzoic acid, 3,6 - dichloro - 2 - methoxy -

RTECS #: DG7525000

CAS #: 1918-00-9

UPDATE: February 2004 MW: 221.04 MF: C8H6Cl2O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2,5 - Dichloro - 6 - methoxybenzoic acid
  2. 2 - Methoxy - 3,6 - dichlorobenzoic acid
  3. 3,6 - Dichloor - 2 - methoxy - benzoeizuur (Dutch)
  4. 3,6 - Dichlor - 3 - methoxy - benzoesaeure (German)
  5. 3,6 - Dichloro - 2 - methoxybenzoic acid
  6. 3,6 - Dichloro - o - anisic acid
  7. Acido (3,6 - dicloro - 2 - metossi) - benzoico (Italian)
  8. Banlen
  9. Banvel 480
  10. Banvel 4WS
  11. Banvel CST
  12. Banvel II herbicide
  1. Banvel herbicide
  2. Brush buster
  3. Compound B dicamba
  4. Dianat (Russian)
  5. Dicamba
  6. Dicamba technical
  7. Kyselina 3,6 - dichlor - 2 - methoxybenzoova (Czech)
  8. MDBA
  9. Mediben
  10. Velsicol 58 - CS - 11
  11. Velsicol compound R
  12. o - Anisic acid, 3,6 - dichloro -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis unreported route
mouse 		500 mg/kg TGANAK 16(1),45,1982
DNA damage intraperitoneal
rat 		17,800 µg/kg EMMUEG 15,131,1990
DNA repair Bacillus subtilis 5 mg/disc NTIS** PB80-133226
DNA repair Escherichia coli 5 mg/disc NTIS** PB80-133226
unscheduled DNA synthesis rat lymphocyte 200 mg/L EMMUEG 15,131,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mammal (species unspecified) 		lowest published toxic dose: 136 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FEREAC 64,761,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 5.3 gm/m3 N/R FEREAC 64,760,1999
oral
guinea pig 		lethal dose (50 percent kill): 3 gm/kg N/R HYSAAV 35(7-9),14,1970
oral
mouse 		lethal dose (50 percent kill): 1,190 mg/kg N/R HYSAAV 35(7-9),14,1970
oral
rat 		lethal dose (50 percent kill): 1,039 mg/kg N/R FAATDF 7,299,1986
oral
rabbit 		lethal dose (50 percent kill): 2 gm/kg N/R HYSAAV 35(7-9),14,1970
skin
rat 		lethal dose (50 percent kill): >1 gm/kg N/R WRPCA2 9,119,1970
skin
rabbit 		lethal dose (50 percent kill): 2,000 mg/kg N/R FEREAC 64,760,1999
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1 gm/kg N/R 30ZDA9 -,147,1971
unreported route
mouse 		lethal dose (50 percent kill): 700 mg/kg N/R TGANAK 16(1),45,1982
unreported route
rat 		lowest published toxic dose: 300 mg/kg Behavioral: Ataxia

Behavioral: Alteration of classical conditioning 		FEREAC 64,761,1999


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 13,244 mg/kg/43 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		GISAAA 47(10),77,1982
oral
rabbit 		lowest published toxic dose: 1,365 mg/kg/26 week- intermittent Liver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		GISAAA 35(10),14,1970


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
JTCTDW 38,111,2000


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,110,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4903;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 1;
Total Number of Employees Exposed 34


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used to control annual and perennial broadleaf weeds in corn, grain sorghum, etc.
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used to control annual and perennial broadleaf weeds in corn, grain sorghum, etc.

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

 Click Here for Additional Information about RTECS