The Registry of Toxic Effects of Chemical Substances

Benzoic acid

RTECS #: DG0875000

CAS #: 65-85-0

UPDATE: November 2003 MW: 122.13 MF: C7H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Acide benzoique (French)
  2. Acido benzoico (Italian)
  3. Benzeneformic acid
  4. Benzenemethanoic acid
  5. Benzoate
  6. Benzenecarboxylic acid
  7. Benzoesaeure (German)
  8. Carboxybenzene
  9. HA 1 (acid)
  10. Kyselina benzoova (Czech)
  1. Phenylcarboxylic acid
  2. Dracylic acid
  3. E 210
  4. Phenylformic acid
  5. Retarder BA
  6. Retardex
  7. Salvo liquid
  8. Salvo powder
  9. Tenn - Plas


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe BIOFX* 28-4/1973
skin
human 		22 mg/3 day- intermittent moderate 85DKA8 -,127,1977
skin
human 		0.25%/1 hour open irritation test moderate ADVEA4 26,734,1984
skin
human 		0.76%/40 minute mild CODEDG 33,177,1995
skin
rabbit 		500 mg/24 hour mild BIOFX* 28-4/1973


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition human lymphocyte 5 mmol/L PNASA6 79,1171,1982
mutation in microorganisms Escherichia coli 10 mmol/L (-enzymatic activation step) ZBPIA9 112,226,1959


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >26 mg/m3/1 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity) 		BIOFX* 28-4/1973
intraperitoneal
guinea pig 		lowest published lethal dose: 1,400 mg/kg N/R HBTXAC 5,23,1959
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,460 mg/kg N/R CRSBAW 160,1097,1966
intraperitoneal
rat 		lethal dose (50 percent kill): 1,600 mg/kg N/R BCFAAI 112,53,1973
intravenous
rat 		lethal dose (50 percent kill): 1,700 mg/kg N/R APYPAY 12,173,1961
oral
guinea pig 		lowest published lethal dose: 2 gm/kg N/R MMWOAU 77,13,1930
oral
man 		lowest published lethal dose: 500 mg/kg N/R FCTXAV 17,715,1979
oral
mouse 		lethal dose (50 percent kill): 1,940 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes 		IYKEDH 15,359,1984
oral
rat 		lethal dose (50 percent kill): 1,700 mg/kg N/R IPSTB3 3,93,1976
oral
rabbit 		lowest published lethal dose: 2 gm/kg N/R HBTXAC 5,23,1959
subcutaneous
frog 		lowest published lethal dose: 100 mg/kg N/R HBTXAC 5,23,1959
subcutaneous
rabbit 		lowest published lethal dose: 2 gm/kg N/R HBTXAC 5,23,1959
skin
human 		lowest published toxic dose: 6 mg/kg Lung, Thorax, or Respiration: Dyspnea

Skin: After systemic exposure: Dermatitis, allergic 		JOALAS 16,195,1945
skin
rabbit 		lethal dose (50 percent kill): >10 gm/kg N/R BIOFX* 28-4/1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,200 mg/m3/4 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0539172


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,297,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 10210;
Number of Industries 35;
Total Number of Facilities 2,798;
Number of Occupations 52;
Total Number of Employees Exposed 77,830
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 10210;
Number of Industries 85;
Total Number of Facilities 9,179;
Number of Occupations 81;
Total Number of Employees Exposed 155,176;
Total Number of Female Employees Exposed 55,139


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of plasticizers, BENZOYL CHLORIDE, SODIUM BENZOATE and alkyl resins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
ADVEA4 Acta Dermato-Venereologica. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.1- 1920-
APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa, Switzerland) V.1-41, 1950-90.
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894-
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher information, see JACIBY.
MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.) V.33-115, 1886-1973.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
ZBPIA9 Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung II. Naturwissenschaftliche: Allgemeine, Landwirtschaftliche und Technische Mikrobiologie. (Jena, Ger. Dem. Rep.) V.107-132, 1952-77.

Used in production of plasticizers, BENZOYL CHLORIDE, SODIUM BENZOATE and alkyl resins

NIOSH PROFILE (ACIDS, ORGANIC), SRI, 2/77

NIOSH PROFILE (ACIDS, ORGANIC), SRC, 4/78

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data
   Primary Irritant

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