The Registry of Toxic Effects of Chemical Substances

Benzoic acid, methyl ester

RTECS #: DH3850000

CAS #: 93-58-3

UPDATE: June 1998 MW: 136.16 MF: C8H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Methyl benzenecarboxylate
  2. Methylester kyseliny benzoove (Czech)
  3. Niobe oil
  1. Essence of niobe
  2. Oil of niobe


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lethal dose (50 percent kill): 4,100 mg/kg N/R FCTXAV 12,937,1974
oral
mouse 		lethal dose (50 percent kill): 3,330 mg/kg Behavioral: Tremor

Behavioral: Excitement 		FCTXAV 2,327,1964
oral
rat 		lethal dose (50 percent kill): 1,177 mg/kg Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair 		FAVUAI 18,69,1986
oral
rabbit 		lethal dose (50 percent kill): 2,170 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Skin and Appendages: Other: Hair 		JPETAB 84,358,1945
skin
cat 		lowest published lethal dose: 10 gm/kg Behavioral: Tremor

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands 		JPETAB 84,358,1945


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 17,400 mg/kg/60 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 49(11),85,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1650;
Number of Industries 3;
Total Number of Facilities 61;
Number of Occupations 6;
Total Number of Employees Exposed 1,002
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1650;
Number of Industries 51;
Total Number of Facilities 4,188;
Number of Occupations 60;
Total Number of Employees Exposed 73,641;
Total Number of Female Employees Exposed 25,030


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as source of BENZOATE radical via ester interchange reaction
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1966-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-

Used as source of BENZOATE radical via ester interchange reaction

RTECS Compound Description:
   Natural Product

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