The Registry of Toxic Effects of Chemical Substances

Benzoic acid, sodium salt

RTECS #: DH6650000

CAS #: 532-32-1

UPDATE: August 2003 MW: 144.11 MF: C7H5O2•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Antimol
  2. Benzoan sodny (Czech)
  3. Benzoate of soda
  4. Benzoate sodium
  1. Benzoesaeure (na - salz) (German)
  2. Sobenate
  3. Sodium benzoate
  4. Sodium benzoic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		10%/1 hour open irritation test N/R DERAAC 26,734,1984
skin
human 		0.5%/20 minute JAADDB 26,734,1984


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 1 gm/L ATSUDG 4,41,1980
cytogenetic analysis hamster fibroblast 2 gm/L/48 hour MUREAV 48,337,1977
sister chromatid exchange human lymphocyte 10 mmol/L MUREAV 241,109,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 3 gm/kg (12-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXAPA9 19,373,1971
intraperitoneal
rat 		lowest published toxic dose: 300 mg/kg (12-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TXAPA9 19,373,1971
oral
rat 		lowest published toxic dose: 44 gm/kg (1-22 day pregnant) Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ESKHA5 (96),47,1978
oral
rat 		lowest published toxic dose: 44 gm/kg (1-22 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) ESKHA5 (96),47,1978


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lethal dose (50 percent kill): 2,306 mg/kg N/R JPETAB 117,307,1956
intraperitoneal
guinea pig 		lowest published lethal dose: 1,400 mg/kg N/R HBAMAK 4,1313,1935
intravenous
mouse 		lethal dose (50 percent kill): 1,440 mg/kg N/R MECHAN 6,290,1963
intravenous
rat 		lethal dose (50 percent kill): 1,714 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		JAPMA8 31,253,1942
oral
dog 		lethal dose (50 percent kill): 2 gm/kg N/R FAONAU 53A,34,1974
oral
mouse 		lethal dose (50 percent kill): 1,600 mg/kg Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 51(1),75,1986
oral
rat 		lethal dose (50 percent kill): 4,070 mg/kg N/R JIHTAB 30,63,1948
oral
rabbit 		lethal dose (50 percent kill): 2 gm/kg N/R FAONAU 53A,34,1974
subcutaneous
frog 		lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1313,1935
subcutaneous
guinea pig 		lowest published lethal dose: 1 gm/kg N/R GISAAA 28(1),45,1963
subcutaneous
rat 		lethal dose (50 percent kill): 2 gm/kg N/R GISAAA 28(1),45,1963
subcutaneous
rabbit 		lethal dose (50 percent kill): 2 gm/kg N/R FAONAU 53A,34,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 45 gm/kg/10 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOLED5 69,171,1993
oral
rat 		lowest published toxic dose: 27,370 mg/kg/10 day- continuous Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins 		TOLED5 69,171,1993
oral
rat 		lowest published toxic dose: 84 gm/kg/28 day- continuous Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIPTAK 144,120,1963
oral
rat 		lowest published toxic dose: 137 gm/kg/13 week- continuous Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TRENAF 42,285,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,297,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80214;
Number of Industries 84;
Total Number of Facilities 13,289;
Number of Occupations 69;
Total Number of Employees Exposed 92,390
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1192;
Number of Industries 2;
Total Number of Facilities 31;
Number of Occupations 2;
Total Number of Employees Exposed 430;
Total Number of Female Employees Exposed 288
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80214;
Number of Industries 143;
Total Number of Facilities 20,457;
Number of Occupations 125;
Total Number of Employees Exposed 533,161;
Total Number of Female Employees Exposed 199,915


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a food and feed additive, flavor, packaging material, pharmaceutical
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
DERAAC Dermatologica. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.79- 1939-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MECHAN Medicinal Chemistry, A Series of Reviews. (New York, NY) V.1-6, 1951-63. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a food and feed additive, flavor, packaging material, pharmaceutical

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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