The Registry of Toxic Effects of Chemical Substances

Benzonitrile, 3,5 - diiodo - 4 - hydroxy -

RTECS #: DI4025000

CAS #: 1689-83-4

UPDATE: November 2003 MW: 370.91 MF: C7H3I2NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. ACP 63303
  2. Actril
  3. Bentrol
  4. Benzonitrile, 4 - hydroxy - 3,5 - diiodo -
  5. CA 69 - 15
  6. Certrol
  7. 4 - Cyano - 2,6 - diiodophenol
  8. 4 - Cyano - 2,6 - dijodphenol (German)
  9. Iotox
  1. Ioxynil
  2. Joxynil
  3. M&B 8873
  4. Trevespan
  5. Cipotril
  6. 3,5 - Diiodo - 4 - hydroxybenzonitrile
  7. 3,5 - Dijod - 4 - hydroxy - benzonitril (German)
  8. 4 - Hydroxy - 3,5 - diiodobenzonitrile


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 6,552 mg/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** OTS0571274


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 380 mg/m3/4 hour Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		NTIS** OTS0555727
inhalation
rat 		lethal concentration (50 percent kill): 400 mg/m3 N/R HBPTO* 2,1229,2001
intravenous
mouse 		lethal dose (50 percent kill): 56 mg/kg N/R CSLNX* NX#02818
oral
domestic bird 		lethal dose (50 percent kill): 30 mg/kg N/R HBPTO* 2,1229,2001
oral
wild bird 		lethal dose (50 percent kill): 75 mg/kg N/R PEMNDP 9,496,1991
oral
cat 		lethal dose (50 percent kill): 75 mg/kg N/R HBPTO* 2,1235,2001
oral
chicken 		lethal dose (50 percent kill): 200 mg/kg N/R 85GYAV -,93,1971
oral
duck 		lethal dose (50 percent kill): 1,200 mg/kg N/R HBPTO* 2,1229,2001
oral
guinea pig 		lethal dose (50 percent kill): 76 mg/kg N/R HBPTO* 2,1235,2001
oral
human 		lowest published lethal dose: 28 mg/kg Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage 		ARTODN 37,241,1977
oral
man 		lowest published lethal dose: 30 mg/kg N/R HBPTO* 2,1236,2001
oral
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R HBPTO* 2,1229,2001
oral
rat 		lethal dose (50 percent kill): 110 mg/kg N/R HBPTO* 2,1229,2001
oral
rabbit 		lethal dose (50 percent kill): 180 mg/kg N/R HBPTO* 2,1235,2001
skin
rat 		lowest published lethal dose: 210 µg/kg N/R GUCHAZ 6,304,1973
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 120 mg/kg N/R 30ZDA9 -,149,1971
unreported route
mouse 		lethal dose (50 percent kill): 230 µg/kg N/R GUCHAZ 6,304,1973
unreported route
rabbit 		lethal dose (50 percent kill): 180 µg/kg N/R GUCHAZ 6,304,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 980 mg/kg/14 week- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight 		NNGADV 16,349,1991
oral
mouse 		lowest published toxic dose: 1,365 mg/kg/78 week- continuous Gastrointestinal: Other changes

Liver: Other changes 		NNGADV 16,349,1991
oral
mouse 		lowest published toxic dose: 2,737.5 mg/kg/78 week- continuous Liver: Other changes

Endocrine: Thyroid weight (goiter) 		HBPTO* 2,1235,2001
oral
mouse 		lowest published toxic dose: 3,650 mg/kg/2 year- continuous Endocrine: Evidence of thyroid hyperfunction HBPTO* 2,1235,2001
oral
rat 		lowest published toxic dose: 980 mg/kg/14 week- continuous Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		NNGADV 16,349,1991
oral
rat 		lowest published toxic dose: 21,900 mg/kg/2 year- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		NNGADV 16,349,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-

Used as a contact herbicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Human Data

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