The Registry of Toxic Effects of Chemical Substances

p - Benzoquinone

RTECS #: DK2625000

CAS #: 106-51-4

UPDATE: February 2005 MW: 108.10 MF: C6H4O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Benzo - chinon (German)
  2. 1,4 - Benzoquine
  3. p - Benzoquinone (OSHA)
  4. 1,4 - Cyclohexadienedione
  5. 2,5 - Cyclohexadiene - 1,4 - dione
  6. 1,4 - Cyclohexadiene dioxide
  7. NCI - C55845
  8. PBQ 2
  9. Quinone
  10. Quinone (ACGIH:OSHA)
  11. p - Quinone
  1. RCRA waste number U197
  2. Steara PBQ
  3. 1,4 - Benzoquinone
  4. Chinon (Dutch, German)
  5. p - Chinon (German)
  6. Chinone
  7. Cyclohexadienedione
  8. 1,4 - Diossibenzene (Italian)
  9. 1,4 - Dioxybenzene
  10. 1,4 - Dioxy - benzol (German)
  11. USAF P - 220


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct human bone marrow 100 µmol/L CRNGDP 12,1181,1991
DNA damage human mammary gland 1 µmol/L/72 hour TOXID9 72,204,2003
DNA damage mouse lymphocyte 4 µmol/L PAACA3 27,81,1986
DNA inhibition mouse lymphocyte 5 µmol/L MOPMA3 28,560,1985
mutation in microorganisms Salmonella typhimurium 8 mg/plate (+enzymatic activation step) MUREAV 81,11,1981
micronucleus test hamster lung 6,700 µmol/L EVHPAZ 82,81,1989
micronucleus test oral
mouse 		20 mg/kg MUREAV 208,61,1988
micronucleus test mouse embryo 50 µmol/L EMMUEG 19(Suppl 20),21,1992
mutation in mammalian somatic cells mouse lymphocyte 2,100 nmol/L MUTAEX 3,193,1988
morphological transform mouse embryo 400 µg/L CRNGDP 16,477,1995
other mutation test systems human lymphocyte 5 µmol/L CNREA8 45,2471,1985
other mutation test systems mouse lymphocyte 10 µmol/L TOLED5 29,161,1985
other mutation test systems mouse other cell types 6 µmol/L CBTOE2 2,231,1986
other mutation test systems rabbit bone marrow 2 µmol/L AJIMD8 7,485,1985
sister chromatid exchange human lymphocyte 5 µmol/L CNREA8 45,2471,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 800 mg/kg/29 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		PIATA8 16,309,1940
skin
mouse 		toxic dose : 6,326 mg/kg/43 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		GANNA2 39,56,1948


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 8,500 µg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis 		BCPCA6 12,885,1963
intraperitoneal
rat 		lethal dose (50 percent kill): 30 mg/kg N/R PHBUA9 3,337,1955
intravenous
rat 		lethal dose (50 percent kill): 25 mg/kg N/R FEPRA7 8,348,1949
oral
mouse 		lethal dose (50 percent kill): 25 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Skin and Appendages: Other: Hair 		NTIS** OTS0571885
oral
mouse 		lowest published toxic dose: 20 mg/kg/12 hour Blood: Changes in bone marrow not included in above MUREAV 208,61,1988
oral
rat 		lethal dose (50 percent kill): 130 mg/kg N/R FEPRA7 8,348,1949
subcutaneous
mammal (species unspecified) 		lethal dose (50 percent kill): 296 mg/kg N/R 85GMAT -,25,1982
subcutaneous
mouse 		lethal dose (50 percent kill): 93,800 µg/kg N/R ZGIMAL 2,333,1947
unreported route
rat 		lethal dose (50 percent kill): 5,600 µg/kg Behavioral: Convulsions or effect on seizure threshold RPTOAN 41,146,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 15,255,1977
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 71,1245,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 15,255,1977
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1245,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1245,1999
TOXICOLOGY REVIEW
MUREAV 566,99,2004
TOXICOLOGY REVIEW
TOLED5 140-141,53,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.4 mg/m3) DTLVS* 3,221,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.4 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 ppm (0.4 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 ppm (0.4 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.4 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.4 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.44 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.4 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.4 mg/m3), short term exposure limit 0.3 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.4 mg/m3), VLE 0.3 ppm (1.5 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (0.4 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.4 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (15 mg/m3), JAN1993
Occupational Exposure Limit - POLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.4 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.1 ppm (0.4 mg/m3), KTV 0.3 ppm (1.3 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.4 mg/m3), KZG- week 0.2 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.45 mg/m3), short term exposure limit 0.3 ppm (1.3 mg/m3), SEP2000
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO QUINONE-air 10 hour time-weighted average 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 66950;
Number of Industries 3;
Total Number of Facilities 145;
Number of Occupations 6;
Total Number of Employees Exposed 3,292
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 66950;
Number of Industries 17;
Total Number of Facilities 1,228;
Number of Occupations 18;
Total Number of Employees Exposed 15,511;
Total Number of Female Employees Exposed 1,274


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as an industrial chemical, chemical intermediate and laboratory reagent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9079;8EHQ-0892-9083
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AJIMD8 American Journal of Industrial Medicine. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1965-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
PHBUA9 Pharmaceutical Bulletin. (Tokyo, Japan) V.1-5, 1953-57. For publisher information, see CPBTAL.
PIATA8 Proceedings of the Imperial Academy of Tokyo. (Tokyo, Japan) V.1-21, 1912-45. For publisher information, see PJACAW.
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
ZGIMAL Zeitschrift fuer die Gesamte Innere Medizin und Ihre Grenzgebiete. (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1946-

Used as an industrial chemical, chemical intermediate and laboratory reagent

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

 Click Here for Additional Information about RTECS