The Registry of Toxic Effects of Chemical Substances

Beryllium chloride

RTECS #: DS2625000

CAS #: 7787-47-5

UPDATE: May 2005 MW: 79.91 MF: BeCl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Beryllium dichloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		0.25%/12 hour VCVN1* -,97,1988


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 750 µg/disc MUREAV 264,163,1991
mutation in microorganisms Escherichia coli 10 µmol/L (-enzymatic activation step) MUREAV 126,9,1984
mutation in mammalian somatic cells hamster lung 2 mmol/L MUREAV 68,259,1979
sister chromatid exchange hamster lung 31 mg/L MUREAV 264,163,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratracheal
rat 		lowest published toxic dose: 1,685 µg/kg (3 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities 		GISAAA 51(8),44,1986
intratracheal
rat 		lowest published toxic dose: 1,685 µg/kg (5 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Other developmental abnormalities 		GISAAA 51(8),44,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 20 µg/m3/1 hour/17 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		GTPZAB 19(7),34,1975


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 1 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature increase 		VCVN1* -,95,1988
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 50 mg/kg N/R EQSSDX 1,1,1975
intraperitoneal
mouse 		lethal dose (50 percent kill): 11,987 µg/kg N/R COREAF 256,1043,1963
intraperitoneal
rat 		lethal dose (50 percent kill): 5,320 µg/kg N/R FEPRA7 9,264,1950
oral
mouse 		lethal dose (50 percent kill): 92 mg/kg N/R VCVN1* -,93,1988
oral
rat 		lethal dose (50 percent kill): 86 mg/kg N/R VCVN1* -,93,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 0.2 mg(Be)/m3/1 hour/16 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVN1* -,95,1988
inhalation
rat 		lowest published toxic concentration: 0.2 mg(Be)/m3/1 hour/78 week- intermittent Lung, Thorax, or Respiration: Bronchogenic carcinoma

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVN1* -,95,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.002 mg(Be)/m3 DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected human carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 23,143,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 58,41,1993
TOXICOLOGY REVIEW
CTOXAO 6,497,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.001 mg(Be)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.006 mg(Be)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.002 mg(Be)/m3, continuous2 Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.001 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - INDIA time-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.002 mg(Be)/m3, 2A Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.001 mg(Be)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.001 mg(Be)/m3, MAC(short term exposure limit) 0.003 mg(Be)/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.001 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.002 mg(Be)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.002 mg(Be)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.005 mg(Be)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.002 mg(Be)/m3, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-air Carcinogen not to exceed 0.0005 mg(Be)/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of BERYLLIUM and as an acid catalyst
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used in manufacture of BERYLLIUM and as an acid catalyst

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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