The Registry of Toxic Effects of Chemical Substances

2,2' - Bipyridine

RTECS #: DW1750000

CAS #: 366-18-7

UPDATE: January 1997 MW: 156.20 MF: C10H8N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. alpha,alpha' - Bipyridyl
  2. 2,2' - Bipyridyl
  3. 2,2' - Bipyridin
  4. Bipyridine
  5. alpha,alpha' - Bipyridine
  1. CI - 588
  2. alpha,alpha' - Dipyridyl
  3. 2,2' - Dipyridyl
  4. alpha,alpha' - Dwupirydylu (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage hamster lung 12,500 µg/L MUREAV 300,223,1993
mutation in microorganisms Salmonella typhimurium 20 µg/plate (+/-enzymatic activation step) ABCHA6 45,327,1981
mutation in mammalian somatic cells hamster lung 14,500 µg/L MUREAV 300,223,1993


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 18,63,1978


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 8,000 mg/kg/40 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors 		JNCIAM 24,109,1960


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 200 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes 		JPETAB 196,478,1976
intraperitoneal
rat 		lethal dose (50 percent kill): 150 mg/kg N/R PJPPAA 27,619,1975
oral
mouse 		lethal dose (50 percent kill): 330 mg/kg N/R USXXAM #3875163
oral
rat 		lethal dose (50 percent kill): 100 mg/kg Behavioral: Muscle weakness

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Hemorrhage 		JTEHD6 10,363,1982
subcutaneous
rat 		lethal dose (50 percent kill): 131 mg/kg N/R JPETAB 135,317,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84441;
Number of Industries 3;
Total Number of Facilities 141;
Number of Occupations 3;
Total Number of Employees Exposed 708
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84441;
Number of Industries 6;
Total Number of Facilities 461;
Number of Occupations 7;
Total Number of Employees Exposed 3,684;
Total Number of Female Employees Exposed 886


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25-44, 1973-92. For publisher information, see PJPAE3
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

Used as a reagent for the determination of IRON

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector

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