The Registry of Toxic Effects of Chemical Substances

Boric acid, disodium salt

RTECS #: ED4588000

CAS #: 1330-43-4

UPDATE: November 2004 MW: 201.22 MF: B4O7•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Anhydrous borax
  2. Borates, tetra, sodium salt, anhydrous (ACGIH)
  3. Borates, tetra, sodium salts (anhydrous)
  4. Borax glass
  5. Disodium tetraborate
  6. FR 28
  1. Fused borax
  2. Rasorite 65
  3. Sodium biborate
  4. Sodium boron oxide
  5. Sodium tetraborate
  6. Sodium tetraborate (Na2B4O7)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 16,750 µg/kg (30 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		EVHPAZ 13,59,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,817 mg/kg N/R VCVN1* -,193,1988
oral
mouse 		lethal dose (50 percent kill): 1,060 mg/kg N/R VCVN1* -,193,1988
oral
rat 		lethal dose (50 percent kill): 1,200 mg/kg N/R VCVN1* -,193,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 26 gm/kg/14 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Xanthine, purine or nucleotides including urate 		TOLED5 10,219,1982
oral
rat 		lowest published toxic dose: 1,312.5 mg/kg/70 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		VCVN1* -,195,1988
oral
rat 		lowest published toxic dose: 283.5 mg/kg/70 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		VCVN1* -,195,1988
oral
rabbit 		lowest published toxic dose: 22,680 mg/kg/12 week- intermittent Blood: Luekopenia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count 		VCVN1* -,195,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3 DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,91,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 1 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 1 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: B0085;
Number of Industries 34;
Total Number of Facilities 1,170;
Number of Occupations 27;
Total Number of Employees Exposed 5,513
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3899;
Number of Industries 1;
Total Number of Facilities 5;
Number of Occupations 1;
Total Number of Employees Exposed 101
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3899;
Number of Industries 87;
Total Number of Facilities 6,225;
Number of Occupations 57;
Total Number of Employees Exposed 78,116;
Total Number of Female Employees Exposed 15,080


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as component in cleaning agents, wood preservatives and fungicides
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as component in cleaning agents, wood preservatives and fungicides

RTECS Compound Description:
   Reproductive Effector

ALT CAS #: 1332-28-1
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