The Registry of Toxic Effects of Chemical Substances

Bromic acid, potassium salt

RTECS #: EF8725000

CAS #: 7758-01-2

UPDATE: August 2004 MW: 167.01 MF: BrO3•K


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. EEC No. E924
  1. Potassium bromate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 85 mg/L GMCRDC 27,95,1981
cytogenetic analysis intraperitoneal
rat 		251 mg/kg MUREAV 240,281,1990
cytogenetic analysis oral
rat 		3 mmol/kg MUREAV 147,274,1985
DNA damage hamster ovary 7.195 mmol/L/4 hour EMMUEG 40,134,2002
DNA damage hamster ovary 2.5 mmol/L/3 hour FCTOD7 42,209,2004
DNA damage mouse leukocyte 7,500 µmol/L CRNGDP 16,335,1995
DNA damage intraperitoneal
mouse 		150 mg/kg MUREAV 493,39,2001
DNA damage oral
mouse 		300 mg/kg MUREAV 493,39,2001
DNA damage pig kidney 7,500 µmol/L CRNGDP 16,335,1995
DNA damage intraperitoneal
rat 		80 mg/kg JJCREP 83,45,1992
DNA repair hamster ovary 5 mmol/L/3 hour FCTOD7 42,209,2004
mutation in microorganisms Salmonella typhimurium 3,333 µg/plate (+enzymatic activation step) EMMUEG 19(Suppl 21),2,1992
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) AMONDS 3,253,1980
micronucleus test hamster lung 125 mg/L MUREAV 272,223,1992
micronucleus test hamster ovary 5 mmol/L/3 hour FCTOD7 42,209,2004
micronucleus test intraperitoneal
mouse 		25 mg/kg FCTOD7 26,487,1988
micronucleus test oral
mouse 		200 mg/kg/24 hour- continuous FCTOD7 26,487,1988
micronucleus test oral
mouse 		87.4 gm/kg/78 week- continuous EMMUEG 36,283,2000
micronucleus test oral
mouse 		4.48 gm/kg/8 week- continuous EMMUEG 36,283,2000
micronucleus test intraperitoneal
rat 		60 mg/kg MUREAV 269,113,1992
sister chromatid exchange rat leukocyte 20 µmol/L MUREAV 300,241,1993
specific locus test mouse other cell types 100 mg/L/4 hour MUREAV 537,21,2003


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 4,200 mg/kg/13 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		JJCREP 78,358,1987
oral
rat 		lowest published toxic dose: 38,500 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		GANNA2 73,335,1982
oral
rat 		toxic dose : 19,635 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Endocrine: Thyroid tumors 		ESKHA5 (100),93,1982
oral
rat 		toxic dose : 19,250 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		GANNA2 73,335,1982
oral
rat 		toxic dose : 10,500 mg/kg/39 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Kidney tumors 		JJCREP 78,358,1987
oral
rat 		toxic dose : 9,625 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Endocrine: Thyroid tumors 		ESKHA5 (100),93,1982
oral
rat 		toxic dose : 9,625 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		EVHPAZ 69,221,1986
oral
rat 		toxic dose : 5,460 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		JJIND8 77,977,1986
oral
rat 		lowest published toxic dose: 2,400 mg/kg/16 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains 		TXCYAC 187,1,2003
oral
rat 		lowest published toxic dose: 57.6 gm/kg/16 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains 		TXCYAC 187,1,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 177 mg/kg N/R MUREAV 223,399,1989
intraperitoneal
rat 		lethal dose (50 percent kill): 50 mg/kg N/R JACTDZ 13,400,1994
oral
child 		lowest published toxic dose: 7,125 µL/kg Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting 		BMJOAE 1,1363,1951
oral
hamster 		lethal dose (50 percent kill): 388 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea 		EVHPAZ 87,309,1990
oral
human 		lowest published toxic dose: 714 mg/kg Ear: Change in acuity

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		NPRNAY 37,278,1984
oral
mouse 		lethal dose (50 percent kill): 289 mg/kg N/R MUREAV 223,399,1989
oral
rat 		lethal dose (50 percent kill): 157 mg/kg Olfaction: Other olfaction effects

Gastrointestinal: Hypermotility, diarrhea 		ESKGA2 37,258,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 336 mg/kg/14 day- continuous Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ESKGA2 37,266,1991
oral
rat 		lowest published toxic dose: 1,260 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		EVHPAZ 87,309,1990
subcutaneous
guinea pig 		lowest published toxic dose: 280 mg/kg/14 day- intermittent Ear: Changes in vestibular functions

Behavioral: Change in motor activity (specific assay) 		TXAPA9 177,103,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 40,207,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 73,481,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 40,207,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,481,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 73,481,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - UNITED KINGDOM Carcinogen, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81949;
Number of Industries 6;
Total Number of Facilities 132;
Number of Occupations 9;
Total Number of Employees Exposed 3,252
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81949;
Number of Industries 10;
Total Number of Facilities 1,458;
Number of Occupations 24;
Total Number of Employees Exposed 26,562;
Total Number of Female Employees Exposed 11,090


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a food and feed additive, flavor and packaging material
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
AMONDS Applied Methods in Oncology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NPRNAY Nephron. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1964-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a food and feed additive, flavor and packaging material

NIOSH PROFILE (HAIRDRESSING and BARBERS), SRC, 6/80

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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