The Registry of Toxic Effects of Chemical Substances

Butane

RTECS #: EJ4200000

CAS #: 106-97-8

UPDATE: November 2004 MW: 58.14 MF: C4H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Butane (ACGIH)
  2. Butanen (Dutch)
  3. n - Butane
  1. Butani (Italian)
  2. Diethyl
  3. Methylethylmethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 280 mg/m3 Brain and Coverings: Changes in surface EEG VCVGH* -,26,1990
inhalation
mouse 		lethal concentration (16 percent kill): 530,000 mg/m3/2 hour N/R VCVGH* -,26,1990
inhalation
mouse 		lethal concentration (50 percent kill): 680,000 mg/m3/2 hour N/R VCVGH* -,26,1990
inhalation
mouse 		lethal concentration (84 percent kill): 860,000 mg/m3/2 hour N/R VCVGH* -,26,1990
inhalation
rat 		lethal concentration (16 percent kill): 537,000 mg/m3/4 hour N/R VCVGH* -,26,1990
inhalation
rat 		lethal concentration (50 percent kill): 658,000 mg/m3/4 hour N/R VCVGH* -,26,1990
inhalation
rat 		lethal concentration (84 percent kill): 790,000 mg/m3/4 hour N/R VCVGH* -,26,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 800 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 566,21,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 500 ppm (1200 mg/m3) DTLWS* 3,12,1973
Occupational Exposure Limit - AUSTRALIA time-weighted average 800 ppm (1900 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 800 ppm (1900 mg/m3) (all isomers), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 800 ppm (1900 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 500 ppm (1200 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 800 ppm (1900 mg/m3), short term exposure limit 1000 ppm (2350 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 800 ppm (1900 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 1000 ppm (2350 mg/m3) (all isomers), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 300 mg/m3, short term exposure limit 900 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1430 mg/m3, 2003
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 500 ppm (1200 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 250 ppm (600 mg/m3), JAN1999
Occupational Exposure Limit - POLAND time-weighted average 1900 mg/m3, short term exposure limit 3000 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 500 ppm, short term exposure limit 300 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 800 ppm (1900 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 600 ppm (1450 mg/m3), short term exposure limit 750 ppm (1810 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 800 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 800 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BUTANE-air 10 hour time-weighted average 800 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 13480;
Number of Industries 55;
Total Number of Facilities 5,871;
Number of Occupations 53;
Total Number of Employees Exposed 61,958
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 13480;
Number of Industries 307;
Total Number of Facilities 69,613;
Number of Occupations 200;
Total Number of Employees Exposed 988,880;
Total Number of Female Employees Exposed 186,786


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

RTECS Compound Description:
   Human Data

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