The Registry of Toxic Effects of Chemical Substances

Butane, 2 - methyl -

RTECS #: EK4430000

CAS #: 78-78-4

UPDATE: May 2004 MW: 72.17 MF: C5H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1,2 - Trimethylethane
  2. 2 - Methylbutane
  3. Ethyldimethylmethane
  1. Isoamylhydride
  2. Isopentane
  3. Isopentane (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 419 gm/m3/2 hour Behavioral: Excitement JPETAB 58,74,1936
inhalation
mouse 		lethal concentration (50 percent kill): 150,000 mg/m3/2 hour N/R VCVGH* -,28,1990
inhalation
rat 		lowest published toxic concentration: 270,000 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,28,1990
inhalation
rat 		lethal concentration (50 percent kill): 280,000 mg/m3/4 hour N/R VCVGH* -,28,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 10 gm/kg/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TIHEEC 1(3),67,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 600 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA MAK 600 ppm (1899 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 500 ppm (1500 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 1000 ppm (2950 mg/m3), JAN1999
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 600 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 600 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 54246;
Number of Industries 6;
Total Number of Facilities 197;
Number of Occupations 9;
Total Number of Employees Exposed 21,748
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 54246;
Number of Industries 5;
Total Number of Facilities 132;
Number of Occupations 13;
Total Number of Employees Exposed 6,605;
Total Number of Female Employees Exposed 1,247


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as expanding agent in POLYSTYRENE foam beads, process solvents
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as expanding agent in POLYSTYRENE foam beads, process solvents

ALT CAS #: 68923-44-4
ALT CAS #: 92046-46-3
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