The Registry of Toxic Effects of Chemical Substances

Calcium chloride

RTECS #: EV9800000

CAS #: 10043-52-4

UPDATE: May 2005 MW: 110.98 MF: CaCl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Calplus
  2. Caltac
  3. Dowflake
  4. Liquidow
  1. Peladow
  2. Snomelt
  3. Superflake anhydrous


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis rat
Ascites tumor 		3,500 mg/kg GANNA2 54,155,1963
unscheduled DNA synthesis intraperitoneal
rat 		2,500 µmol/kg JOENAK 65,45,1975
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 200 mmol/L MUTAEX 1,21,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 112 gm/kg/20 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors 		AJCAA7 23,550,1935


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraarterial
guinea pig 		lowest published lethal dose: 300 mg/kg N/R AEPPAE 131,171,1928
intraduodenal
dog 		lowest published toxic dose: 555 mg/kg/1 hour Gastrointestinal: Alteration in gastric secretion AJPHAP 248,G28,1985
intramuscular
rat 		lethal dose (50 percent kill): 25 mg/kg N/R EMSUA8 4,223,1946
intraperitoneal
mouse 		lethal dose (50 percent kill): 210 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay) 		GTPZAB 34(5),51,1990
intraperitoneal
mouse 		lethal dose (50 percent kill): 600 mg/kg N/R VCVN1* -,118,1988
intraperitoneal
mouse 		lethal dose : 399.5 mg/kg N/R JTCTDW 39,349,2001
intraperitoneal
rat 		lethal dose (50 percent kill): 264 mg/kg N/R OYYAA2 14,963,1977
intravenous
cat 		lowest published lethal dose: 249 mg/kg N/R HBAMAK 4,1316,1935
intravenous
dog 		lowest published lethal dose: 274 mg/kg N/R HBAMAK 4,1316,1935
intravenous
dog 		lowest published toxic dose: 39.95 mg/kg/15 minute Gastrointestinal: Alteration in gastric secretion AJPHAP 248,G28,1985
intravenous
guinea pig 		lowest published lethal dose: 150 mg/kg N/R AEPPAE 131,171,1928
intravenous
mouse 		lethal dose (50 percent kill): 42 mg/kg N/R TXAPA9 22,150,1972
intravenous
rat 		lowest published lethal dose: 161 mg/kg N/R JLCMAK 15,35,1929
intravenous
rat 		lowest published toxic dose: 300 mg/kg Cardiac: Arrythmias (indlucing changes in conduction) FATOAO 51,50,1988
intravenous
rabbit 		lowest published lethal dose: 274 mg/kg N/R HBAMAK 4,1316,1935
intravenous
woman 		lowest published toxic dose: 20 mg/kg/1 hour- continuous Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Changes in: Ca 		ARDEAC 124,922,1988
oral
mouse 		lethal dose (50 percent kill): 1,940 mg/kg N/R OYYAA2 14,963,1977
oral
rat 		lethal dose (50 percent kill): 1 gm/kg N/R CNJMAQ 12,216,1948
oral
rabbit 		lowest published lethal dose: 1,384 mg/kg N/R HBAMAK 4,1316,1935
oral
rabbit 		lethal dose (50 percent kill): 1,384 mg/kg N/R VCVN1* -,118,1988
parenteral
rat 		lowest published toxic dose: 200 µg/kg Cardiac: Arrythmias (indlucing changes in conduction) PCJOAU 37,6,2003
subcutaneous
cat 		lowest published lethal dose: 249 mg/kg N/R HBAMAK 4,1316,1935
subcutaneous
dog 		lowest published lethal dose: 274 mg/kg N/R HBAMAK 4,1316,1935
subcutaneous
frog 		lowest published lethal dose: 666 mg/kg N/R HBAMAK 4,1316,1935
subcutaneous
mouse 		lethal dose (50 percent kill): 823 mg/kg N/R OYYAA2 14,963,1977
subcutaneous
rat 		lethal dose (50 percent kill): 2,630 mg/kg N/R OYYAA2 14,963,1977
subcutaneous
rabbit 		lowest published lethal dose: 472 mg/kg N/R HBAMAK 4,1316,1935


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 43 mg/m3/4 hour/17 week- intermittent Blood: Change in clotting factors

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		GTPZAB 34(5),51,1990
oral
rat 		lowest published toxic dose: 2,016 mg/kg/30 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Cardiac: Pulse rate decreased with fall in BP

Blood: Changes in leukocyte (WBC) count 		GTPZAB 34(5),51,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
BJMRDK 34,449,2001
TOXICOLOGY REVIEW
TPHSDY 23,63,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,317,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 15720;
Number of Industries 87;
Total Number of Facilities 7,996;
Number of Occupations 79;
Total Number of Employees Exposed 110,691
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 15720;
Number of Industries 116;
Total Number of Facilities 15,168;
Number of Occupations 113;
Total Number of Employees Exposed 354,620;
Total Number of Female Employees Exposed 117,433


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as dust suppressant in food and pharmaceutical industries
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40. For publisher information, see CNREA8.
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898-
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960-
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
CNJMAQ Canadian Journal of Comparative Medicine and Veterinary Science. (Gardenvale, Quebec, Canada) V.4-32, 1940-68. For publisher information, see CJVRE9.
EMSUA8 Experimental Medicine and Surgery. (Brooklyn, NY) V.1-29, 1943-71. Suspended.
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915-
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as dust suppressant in food and pharmaceutical industries

Top 50 chemical production: 1.39 billions lbs in 1992, 1.29 billions in 1991

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Hormone

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