The Registry of Toxic Effects of Chemical Substances

Camphor

RTECS #: EX1225000

CAS #: 76-22-2

UPDATE: November 2004 MW: 152.26 MF: C10H16O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,7,7 - Trimethylbicyclo (2.2.1) - 2 - heptanone
  2. 2 - Bornanone
  3. 2 - Camphanone
  4. 2 - Kamfanon (Czech)
  5. 2 - Keto - 1,7,7 - trimethylnorcamphane
  6. Bicyclo (2.2.1) heptan - 2 - one, 1,7,7 - trimethyl -
  7. Bornane, 2 - oxo -
  8. Camphor, natural
  9. Camphor, synthetic
  1. Camphor, synthetic (ACGIH:OSHA)
  2. Formosa camphor
  3. Gum camphor
  4. Huile de camphre (French)
  5. Japan camphor
  6. Kampfer (German)
  7. Laurel camphor
  8. Matricaria camphor
  9. Norcamphor, 1,7,7 - trimethyl -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange intraperitoneal
mouse 		80 mg/kg MUREAV 224,157,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 400 mg/m3/3 hour Behavioral: Muscle contraction or spasticity GISAAA 22(11),83,1957
inhalation
mouse 		lethal concentration (50 percent kill): 450 mg/m3 Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Gastrointestinal: Nausea or vomiting 		VCVPS* -,296,1998
inhalation
rat 		lethal concentration (50 percent kill): 500 mg/m3 N/R VCVPS* -,296,1998
intraperitoneal
cat 		lowest published lethal dose: 400 mg/kg N/R HBAMAK 4,1289,1935
intraperitoneal
mouse 		lethal dose (50 percent kill): 3 gm/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Behavioral: Rigidity (includes catalepsy) 		AJPAA4 30,857,1954
intraperitoneal
rat 		lowest published lethal dose: 900 mg/kg Behavioral: Convulsions or effect on seizure threshold JPETAB 65,275,1939
oral
child 		lowest published toxic dose: 51 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		AJEMEN 7,41,1989
oral
dog 		lowest published lethal dose: 800 mg/kg N/R HBAMAK 4,1289,1935
oral
infant 		lowest published lethal dose: 70 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		AJPAA4 30,857,1954
oral
mouse 		lethal dose (50 percent kill): 1,310 mg/kg N/R SHGKA3 75,934,1975
oral
rabbit 		lowest published lethal dose: 2 gm/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Behavioral: Rigidity (includes catalepsy) 		AJPAA4 30,857,1954
subcutaneous
frog 		lowest published lethal dose: 240 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change AEXPBL 50,199,1903
subcutaneous
mouse 		lowest published lethal dose: 200 mg/kg Behavioral: Excitement HDTU** -,-,1933
subcutaneous
rat 		lethal dose (50 percent kill): 70 mg/kg N/R CDGU** -,-,1934
unreported route
child 		lowest published lethal dose: 100 mg/kg N/R YKYUA6 31,1499,1980
unreported route
human 		lowest published toxic dose: 0.1 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression 		VCVPS* -,296,1998
unreported route
man 		lowest published lethal dose: 29 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 210 mg/m3/3 hour/7 week- intermittent Lung, Thorax, or Respiration: Emphysema GISAAA 22(11),83,1957
inhalation
rabbit 		lowest published toxic concentration: 33 mg/m3/3 hour/7 week- intermittent Brain and Coverings: Other degenerative changes

Cardiac: Other changes

Lung, Thorax, or Respiration: Emphysema 		GISAAA 22(11),83,1957


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm;short term exposure limit 3 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 3 ppm DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
JRPMAP 12,27,1974
TOXICOLOGY REVIEW
NTIS** PB293-503


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,267,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 ppm (12 mg/m3) DTLVS* 3,37,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (12 mg/m3), short term exposure limit 3 ppm (18 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 2 ppm (13 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (12 mg/m3), short term exposure limit 3 ppm (19 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.3 ppm (2 mg/m3), short term exposure limit 0.9 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 2 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 2 ppm (13 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 2 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 12 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2 ppm, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 3 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (13 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 ppm (13 mg/m3), short term exposure limit 3 ppm (19 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 3 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 3 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAMPHOR, synthetic-air 10 hour time-weighted average 2 mg/m3 NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 15800;
Number of Industries 68;
Total Number of Facilities 8,356;
Number of Occupations 63;
Total Number of Employees Exposed 95,578
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1190;
Number of Industries 1;
Total Number of Facilities 25;
Number of Occupations 1;
Total Number of Employees Exposed 427;
Total Number of Female Employees Exposed 176
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 15800;
Number of Industries 101;
Total Number of Facilities 9,166;
Number of Occupations 87;
Total Number of Employees Exposed 153,554;
Total Number of Female Employees Exposed 53,187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a topical anti-infective and topical antipruritic
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
CDGU** "Ueber die Pharmakologische Wirkung eines dem Pentamethylentetrazol (Cardiazol) nahestehenden stickstoffhaltigen Kampherab-Kommlings, Dissertation," Czygan, H.H., Hessischen Ludwigs- Universitat zu Giessen, Fed. Rep. Ger., 1934
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HDTU** "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SHGKA3 Shika Gakuho. Journal of Dentistry. (Tokyo Shika Daigaku Gakkai, 1-2-2 Masago, Chiba 260, Japan) V.1- 1895-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as a topical anti-infective and topical antipruritic

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Human Data
   Natural Product

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