The Registry of Toxic Effects of Chemical Substances

Carbamic acid, methyl - , o - isopropoxyphenyl ester

RTECS #: FC3150000

CAS #: 114-26-1

UPDATE: November 2004 MW: 209.27 MF: C11H15NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 (1 - Methylethoxy) phenol methyl carbamate
  2. 2 - (1 - Methylethoxy) phenol methylcarbamate
  3. 2 - Isopropoxyphenyl N - methylcarbamate
  4. 2 - Isopropoxyphenyl - N - methylcarbamat (German)
  5. 2 - Isopropoxyphenyl - N - methylcarbamate
  6. Arprocarb
  7. BAY 39007
  8. BAY 5122
  9. Bayer 39007
  10. Bayer B 5122
  11. Baygon
  12. Baygon (OSHA)
  13. Blattanex
  14. Blattosep
  15. Carbamic acid, methyl - , 2 - (1 - methylethoxy) phenyl ester
  16. Chemagro 9010
  17. ENT 25,671
  1. Invisi - Gard
  2. OMS - 33
  3. PHC (carbamate)
  4. PHC 7
  5. Phenol, o - isopropoxy - , methylcarbamate
  6. Propoksuru (Polish)
  7. Propoxur
  8. Propoxur (ACGIH)
  9. Propoxylor
  10. Sendran
  11. Suncide
  12. Tendex
  13. Tugon fliegenkugel
  14. Unden (pesticide)
  15. n - 2 - (1 - Methylethoxy) phenyl methyl - carbamate
  16. o - IMPC
  17. o - Isopropoxyphenyl N - methylcarbamate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intraperitoneal
hamster 		250 mg/kg ARTODN 58,152,1986
dominant lethal test oral
mouse 		125 mg/kg/5 day- continuous GISAAA 44(7),75,1979
mutation in microorganisms Salmonella typhimurium 250 ng/plate (+enzymatic activation step) RPZHAW 30,81,1979
mutation in microorganisms Saccharomyes cerevisiae 5 ppm (-enzymatic activation step) RSTUDV 6,161,1976
micronucleus test human lymphocyte 50 mg/L MUREAV 232,45,1990
sister chromatid exchange hamster lung 200 mg/L CRNGDP 19,623,1998
sister chromatid exchange human lymphocyte 50 mg/L MUREAV 232,45,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 600 mg/kg (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		JPFCD2 20,373,1985
oral
mouse 		lowest published toxic dose: 50 mg/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JPFCD2 20,373,1985
oral
rat 		lowest published toxic dose: 1,600 mg/kg (6-22 day pregnant/15 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Other postnatal measures or effects 		BECTA6 20,624,1978
oral
rat 		lowest published toxic dose: 650 mg/kg (7-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JPFCD2 20,373,1985


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 1,440 mg/m3/1 hour N/R 85GYAV -,70,1971
inhalation
rat 		lethal concentration (50 percent kill): 1,440 mg/m3 N/R HBPTO* 2,1094,2001
intramuscular
rat 		lethal dose (50 percent kill): 53 mg/kg N/R BJIMAG 22,317,1965
intraperitoneal
hamster 		lethal dose (50 percent kill): 500 mg/kg N/R ARTODN 58,152,1986
intraperitoneal
mouse 		lethal dose (50 percent kill): 12 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JAFCAU 16,561,1968
intraperitoneal
rat 		lethal dose (50 percent kill): 30 mg/kg Behavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		BWHOA6 44,241,1971
intravenous
rat 		lethal dose (50 percent kill): 11 mg/kg N/R BJIMAG 22,317,1965
intravenous
rabbit 		lethal dose (50 percent kill): 5 mg/kg Lung, Thorax, or Respiration: Other changes TXAPA9 165,27,2000
oral
wild bird 		lethal dose (50 percent kill): 3,800 µg/kg N/R TXAPA9 21,315,1972
oral
chicken 		lethal dose (50 percent kill): 46,500 µg/kg Behavioral: Convulsions or effect on seizure threshold TXAPA9 7,606,1965
oral
duck 		lethal dose (50 percent kill): 9,580 µg/kg N/R TXAPA9 22,556,1972
oral
dog 		lowest published toxic dose: 5 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 1,697,2001
oral
dog 		lowest published toxic dose: 2 mg/kg Eye: Other eye effects

Gastrointestinal: Other changes

Skin and Appendages: Other: Sweating 		HBPTO* 1,697,2001
oral
guinea pig 		lethal dose (50 percent kill): 40 mg/kg N/R HBPTO* 2,1094,2001
oral
human 		lowest published toxic dose: 0.36 mg/kg Olfaction: Other olfaction effects

Gastrointestinal: Hypermotility, diarrhea 		HBPTO* 1,697,2001
oral
human 		lowest published toxic dose: 0.36 mg/kg Eye: Other eye effects

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1097,2001
oral
human 		lowest published toxic dose: 1.5 mg/kg Behavioral: Headache

Cardiac: Pulse rate increased without fall in BP

Gastrointestinal: Nausea or vomiting 		HBPTO* 2,1097,2001
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 90 mg/kg N/R HPBIA9 21,53,1975
oral
mouse 		lethal dose (50 percent kill): 23,500 µg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		TOIZAG 17,60,1970
oral
mouse 		lethal dose (50 percent kill): 37 mg/kg N/R HBPTO* 2,1094,2001
oral
pigeon 		lethal dose (50 percent kill): 7,500 µg/kg N/R ASTTA8 (680),157,1979
oral
quail 		lethal dose (50 percent kill): 28 mg/kg N/R TXAPA9 20,57,1971
oral
rat 		lethal dose (50 percent kill): 41 mg/kg N/R YKYUA6 37,1621,1986
oral
rat 		lowest published toxic dose: 25 mg/kg Behavioral: Muscle contraction or spasticity HBPTO* 1,697,2001
oral
rabbit 		lowest published lethal dose: 30 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Somnolence (general depressed activity) 		HBPTO* 1,697,2001
oral
woman 		lowest published lethal dose: 24 mg/kg Behavioral: Coma

Cardiac: Pulse rate decreased with fall in BP

Blood: Change in clotting factors 		PGMJAO 63,311,1987
subcutaneous
mouse 		lethal dose (50 percent kill): 11,400 µg/kg N/R TOIZAG 17,60,1970
subcutaneous
rat 		lethal dose (50 percent kill): 56 mg/kg N/R YKYUA6 32,471,1981
skin
mammal (species unspecified) 		lethal dose (50 percent kill): 800 mg/kg N/R PSTDAN 15(10),37,1981
skin
mouse 		lethal dose (50 percent kill): >1,360 mg/kg N/R YKYUA6 31,711,1980
skin
rat 		lethal dose (50 percent kill): 800 mg/kg N/R RPZHAW 22,579,1971
skin
rabbit 		lowest published toxic dose: 2,000 mg/kg N/R HBPTO* 1,697,2001
skin
rabbit 		lethal dose (50 percent kill): 500 mg/kg N/R HBPTO* 2,1094,2001
skin
rabbit 		lowest published toxic dose: 2,000 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity 		HBPTO* 1,697,2001
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 100 mg/kg N/R GISAAA 41(8),82,1976
unreported route
rat 		lethal dose (50 percent kill): 100 mg/kg N/R 30ZDA9 -,193,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 864 mg/kg/13 week- intermittent Gastrointestinal: Other changes

Biochemical: Metabolism (intermediary): Other 		KHZDAN 22(6),584,1979
oral
rat 		lowest published toxic dose: 37,500 µg/kg/50 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Endocrine: Changes in thymus weight

Biochemical: Metabolism (intermediary): Other proteins 		TXAPA9 27,465,1974
oral
rat 		lowest published toxic dose: 180 mg/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		BECTA6 23,438,1979
oral
rat 		lowest published toxic dose: 1,000 mg/kg/50 day- continuous Behavioral: Change in psychophysiological tests HBPTO* 2,1100,2001
oral
rat 		lowest published toxic dose: 238.28 mg/kg/4 week- intermittent Endocrine: Changes in thymus weight

Blood: Changes in erythrocyte (RBC) count 		TXCYAC 178,161,2002
oral
rat 		lowest published toxic dose: 238 mg/kg/4 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight 		TXCYAC 178,161,2002
oral
rat 		lowest published toxic dose: 714 mg/kg/12 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Endocrine: Changes in thymus weight 		TXCYAC 178,161,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
NEJMAG 342,186,2000


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,203,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.5 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JAN1993
Occupational Exposure Limit - FRANCE VME 0.5 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 2 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg/m3, short term exposure limit 2 mg/m3, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(Se)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPOXUR-air 10 hour time-weighted average 0.5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1931;
Number of Industries 18;
Total Number of Facilities 2,519;
Number of Occupations 14;
Total Number of Employees Exposed 18,098
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1931;
Number of Industries 15;
Total Number of Facilities 2,701;
Number of Occupations 16;
Total Number of Employees Exposed 27,304;
Total Number of Female Employees Exposed 4,206


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
Used as an agricultural chemical and pesticide
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49 Sheridan Ave., Albany, NY 12210)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HPBIA9 Herba Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.11- 1965-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
PSTDAN Pesticides. (Colour Pub. Pvt. Ltd., 126-A Dhuruwadi, Off Dr. Nariman Rd., Bombay 400-025, India) V.1- 1967-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued.
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as an agricultural chemical and pesticide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

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