The Registry of Toxic Effects of Chemical Substances

Carbon Black

RTECS #: FF5800000

CAS #: 1333-86-4

UPDATE: November 2004 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acetylene Black
  2. Aroflow
  3. Arogen
  4. Arotone
  5. Arovel
  6. Arrow
  7. Atlantic
  8. Black pearls
  9. C.I. 77266
  10. C.I. Pigment Black 6
  11. Regal SRF
  12. Regent
  13. Royal spectra
  14. Sevacarb
  15. Seval
  16. Shawinigan Acetylene Black
  17. Shell carbon
  18. Special Black 1V & V
  19. Special schwarz
  20. Spheron
  21. C.I. Pigment Black 7
  22. Spheron 6
  23. Statex
  24. Statex N 550
  25. Sterling MT
  26. Sterling N 765
  27. Sterling NS
  28. Sterling SO 1
  29. Super - carbovar
  30. Super - spectra
  31. Superba
  32. CK3
  33. TM 30
  34. Texas
  35. Therma - atomic Black
  36. Thermal Acetylene Black
  37. Thermatomic
  38. Thermax
  39. Thermblack
  40. Tinolite
  41. Toka Black 4500
  42. Toka Black 5500
  43. Cancarb
  44. Toka Black 8500
  45. Torch Brand
  46. Ucet
  47. Ukarb
  48. United
  49. Velvetex
  50. Vulcan
  51. Witco
  52. Witcoblak No. 100
  53. Wyex
  54. Carbodis
  55. Carbolac
  56. Carbolac 1
  57. Carbomet
  58. Carbon Black (ACGIH:OSHA)
  59. Carbon Black BV and V
  60. Carbon black, acetylene
  61. Carbon black, channel
  62. Carbon black, furnace
  63. Carbon black, lamp
  64. Carbon black, thermal
  65. Channel Black
  66. Collocarb
  67. Colloidal - carbon
  68. Columbia carbon
  69. Conductex 900
  70. Continex
  1. Corax A
  2. Corax P
  3. Croflex
  4. Crolac
  5. Degussa
  6. Delussa Black FW
  7. Durex O
  8. ELF 78
  9. Eagle Germantown
  10. Elftex
  11. Essex
  12. Excelsior
  13. Explosion Acetylene Black
  14. Explosion Black
  15. Farbruss
  16. Fecto
  17. Flamruss
  18. Furnal
  19. Furnex
  20. Furnex N 765
  21. Gas - furnace black
  22. Gastex
  23. Huber
  24. Humenegro
  25. Impingement Black
  26. Ketjenblack EC
  27. Kosmink
  28. Kosmobil
  29. Kosmolak
  30. Kosmos
  31. Kosmotherm
  32. Kosmovar
  33. Magecol
  34. Metanex
  35. Micronex
  36. Miike 20
  37. Modulex
  38. Mogul
  39. Mogul L
  40. Molacco
  41. Monarch 1300
  42. Neo Spectra Beads AG
  43. Neo - Spectra Mark II
  44. Neotex
  45. Oil - furnace Black
  46. P 33 (carbon black)
  47. P1250
  48. P68
  49. Peach black
  50. Pelletex
  51. Philblack
  52. Philblack N 550
  53. Philblack N 765
  54. Philblack O
  55. Pigment Black 7
  56. Printex
  57. Printex 60
  58. Raven
  59. Raven 30
  60. Raven 420
  61. Raven 500
  62. Raven 8000
  63. Rebonex
  64. Regal
  65. Regal 300
  66. Regal 330
  67. Regal 400R
  68. Regal 600
  69. Regal 99


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct inhalation
mouse 		6,200 µg/m3/16 hour/12 week- intermittent EMMUEG 16,64,1990
DNA damage human lymphocyte 16 µg/L/48 hour EMMUEG 37,155,2001
DNA damage inhalation
rat 		50 µg/L/13 week- intermittent TXAPA9 190,224,2003
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) EVSRBT 27,297,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 11,600 µg/m3/18 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		INHTE5 7,533,1995


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 7 mg/m3 Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOXID9 72,289,2003
intratracheal
mouse 		lowest published toxic dose: 20 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOXID9 72,288,2003
intravenous
rat 		lowest published toxic dose: 10 mg/kg/2 minute Liver: Changes in liver weight

Blood: Changes in spleen 		XENOBH 10,,1980
intravenous
rat 		lowest published toxic dose: 10 mg/kg/2 minute Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) BCPCA6 30,,1981
oral
rat 		lethal dose (50 percent kill): >15,400 mg/kg Behavioral: Somnolence (general depressed activity) ATDAEI 15(Suppl 1),S28,1996
skin
rabbit 		lethal dose (50 percent kill): >3 gm/kg N/R ATDAEI 15(Suppl 1),S28,1996


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lowest published toxic concentration: 7 mg/m3/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOXID9 72,288,2003
inhalation
mouse 		lowest published toxic concentration: 7 mg/m3/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOXID9 72,288,2003
inhalation
rat 		lowest published toxic concentration: 50 mg/m3/6 hour/90 day- intermittent Lung, Thorax, or Respiration: Other changes TOXID9 15,46,1995
inhalation
rat 		lowest published toxic concentration: 7 mg/m3/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOXID9 72,289,2003
skin
rat 		lowest published toxic dose: 11 gm/kg/4 week- intermittent Blood: Pigmented or nucleated red blood cells

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0534753


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 3.5 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 65,149,1996
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 33,35,1984
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 33,35,1984
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 65,149,1996
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 65,149,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 3.5 mg/m3 DTLVS* 3,38,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 3.5 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 3.5 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 3.5 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 3.5 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 3 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 3.5 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 3.5 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 3.5 mg/m3, short term exposure limit 7 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 3.5 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 3.5 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 3.5 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3.5 mg/m3, 2003
Occupational Exposure Limit - SWEDEN NGV 3 mg/m3 (dust), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 3.5 mg/m3, short term exposure limit 7 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CARBON BLACK-air Carcinogen;
10 hour time-weighted average 3.5 mg/m3 in pres. of PAHs 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0647;
Number of Industries 159;
Total Number of Facilities 19,312;
Number of Occupations 88;
Total Number of Employees Exposed 172,738
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0647;
Number of Industries 376;
Total Number of Facilities 108,610;
Number of Occupations 206;
Total Number of Employees Exposed 1,728,518;
Total Number of Female Employees Exposed 369,253
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7126;
Number of Industries 1;
Total Number of Facilities 22;
Number of Occupations 1;
Total Number of Employees Exposed 129;
Total Number of Female Employees Exposed 65


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as reinforcing agent and filler for rubber, colorants for ink, paint and plastics
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Carbon black, 5000
OSHA ANALYTICAL METHOD #ID196


REFERENCES:

CODEN
REFERENCE
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
XENOBH Xenobiotica. (Taylor & Francis Ltd., 4 John St., London WC1N 2ET, UK) V.1- 1971-

Used as reinforcing agent and filler for rubber, colorants for ink, paint and plastics

Top 50 chemical production: 3.02 billions lbs in 1992, 2.72 billions in 1991

NIOSH PROFILE (CARBON BLACK), SRC, 10/77

NIOSH PROFILE (PRINTING INDUSTRY), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen

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