The Registry of Toxic Effects of Chemical Substances

Carbonic acid, diethyl ester

RTECS #: FF9800000

CAS #: 105-58-8

UPDATE: January 1997 MW: 118.15 MF: C5H10O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. DEC
  2. Diatol
  3. Diethylester kyseliny uhlicite (Czech)
  4. Diethylkarbonat (Czech)
  1. Ethoxyformic anhydride
  2. Ethyl carbonate
  3. Eufin
  4. NCI - C60899


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
hamster 		lowest published toxic dose: 496 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		CNREA8 27,1696,1967
intraperitoneal
hamster 		lowest published toxic dose: 496 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) CNREA8 27,1696,1967
intraperitoneal
hamster 		lowest published toxic dose: 1,004 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Body wall 		CNREA8 27,1696,1967


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 456 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		BCPCA6 2,168,1959
oral
mouse 		lowest published toxic dose: 500 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		BCPCA6 2,168,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published lethal dose: 15 gm/kg N/R FAONAU 53A,52,1974
subcutaneous
rat 		lethal dose (50 percent kill): 8,500 mg/kg N/R CLDND*


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1089;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 2;
Total Number of Employees Exposed 83
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1089;
Number of Industries 3;
Total Number of Facilities 415;
Number of Occupations 8;
Total Number of Employees Exposed 6,967;
Total Number of Female Employees Exposed 1,022


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.

Used in synthesis of pharmaceuticals, agricultural products, and veterinary medicine

RTECS Compound Description:
   Tumorigen
   Drug
   Reproductive Effector

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