RTECS:FO2800000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Chlorine fluoride

RTECS #: FO2800000

CAS #: 7790-91-2

UPDATE: November 2004 MW: 92.45 MF: ClF₃

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Chlorine trifluoride

Chlorine trifluoride (ACGIH:OSHA)

Chlorotrifluoride

Trifluorure de chlore (French)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
dog 21 ppm/12 hour- intermittent N/R AMIHAB 12,515,1955
eye
rat 21 ppm/12 hour- intermittent N/R AMIHAB 12,515,1955

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
dog lowest published toxic concentration: 1,800 mg/m³/2 minute Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough VCVN5* -,386,1989
inhalation
dog lowest published toxic concentration: 1,800 mg/m³/5 minute Eye: Lacrimation

Eye: Corneal damage VCVN5* -,386,1989
inhalation
dog lowest published lethal concentration: 360 mg/m³/4 hour N/R VCVN5* -,386,1989
inhalation
human lowest published lethal concentration: 50 ppm N/R 34ZIAG -,651,1966
inhalation
mammal (species unspecified) lowest published toxic concentration: 80 mg/m³/10 minute Lung, Thorax, or Respiration: Cough VCVN5* -,386,1989
inhalation
monkey lethal concentration (50 percent kill): 230 ppm/1 hour Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis AMRL TR-70-77,1970
inhalation
mouse lethal concentration (50 percent kill): 178 ppm/1 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis AMRL TR-70-77,1970
inhalation
rat lethal concentration (50 percent kill): 299 ppm/1 hour N/R TXAPA9 42,417,1977
inhalation
rat lowest published lethal concentration: 3,000 mg/m³/15 minute N/R VCVN5* -,385,1989
inhalation
rat lowest published lethal concentration: 1,500 mg/m³/35 minute N/R VCVN5* -,386,1989
inhalation
rabbit lowest published toxic concentration: 1,800 mg/m³/2 minute Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough VCVN5* -,386,1989
inhalation
rabbit lowest published toxic concentration: 1,800 mg/m³/5 minute Eye: Lacrimation

Eye: Corneal damage VCVN5* -,386,1989
inhalation
rabbit lowest published lethal concentration: 360 mg/m³/4 hour N/R VCVN5* -,386,1989

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
dog lowest published toxic concentration: 5,150 ppb/6 hour/6 week- intermittent Eye: Corneal damage

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHAB 12,515,1955
inhalation
dog lowest published toxic concentration: 1,170 ppb/6 hour/26 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHAB 13,340,1956
inhalation
dog lowest published toxic concentration: 20 mg/m³/6 hour/6 week- intermittent Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,386,1989
inhalation
mammal (species unspecified) lowest published toxic concentration: 2 mg/m³/17 week- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Musculoskeletal: Other changes STGNBT -,239,1999
inhalation
mammal (species unspecified) lowest published toxic concentration: 4 mg/m³/6 hour/26 week- intermittent Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough VCVN5* -,386,1989
inhalation
mammal (species unspecified) lowest published toxic concentration: 4 mg/m³/6 hour/8 week- intermittent Lung, Thorax, or Respiration: Other changes VCVN5* -,386,1989
inhalation
rat lowest published toxic concentration: 5,150 ppb/6 hour/6 week- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Changes in structure or function of salivary glands

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHAB 12,515,1955
inhalation
rat lowest published toxic concentration: 1,170 ppb/6 hour/26 week- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHAB 13,340,1956
inhalation
rat lowest published toxic concentration: 20 mg/m³/6 hour/6 week- intermittent Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,386,1989

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.1 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
TXAPA9 27,527,1974

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 0.1 ppm (0.4 mg/m³) DTLWS* 3,11,1972
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.1 ppm (0.4 mg/m³) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.1 ppm (0.4 mg/m³) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.1 ppm (0.4 mg/m³) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.1 ppm (0.4 mg/m³) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.4 mg/m³), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.4 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM short term exposure limit 0.1 ppm (0.38 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.4 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (0.4 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE VLE 0.4 mg/m³, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (0.4 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 0.4 mg/m³, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.4 mg/m³), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg(HF)/m³, MAC(short term exposure limit) 3 mg(HF)/m³, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.4 mg/m³), KZG- week 0.2 ppm (0.8 mg/m³), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 ppm (0.4 mg/m³), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.1 ppm (0.38 mg/m³), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 0.1 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 0.1 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORINE TRIFLUORIDE-air ceiling concentration 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 18050;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 3;
Total Number of Employees Exposed 357

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in fluorinations and nuclear fuel processing and as rocket propellant and igniter

NIOSH PROFILE (CHLORINES, INORGANIC), SRC, 4/78

RTECS Compound Description:
Human Data
Primary Irritant

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