The Registry of Toxic Effects of Chemical Substances

Chromium (III) chloride (1:3)

RTECS #: GB5425000

CAS #: 10025-73-7

UPDATE: May 2004 MW: 158.35 MF: Cl3Cr


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. C.I. 77295
  2. Chromic chloride
  3. Chromium chloride
  4. Chromium trichloride
  1. Chromium (III) chloride, anhydrous
  2. Puratronic chromium chloride
  3. Trichlorochromium


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 50 µg/L CARYAB 32,379,1979
cytogenetic analysis human lymphocyte 2,500 µg/L MUREAV 191,207,1987
cytogenetic analysis human fibroblast 100 µmol/L CARYAB 32,379,1979
cytogenetic analysis human other cell types 500 mg/L BJCAAI 44,219,1981
DNA damage human lymphocyte 600 µmol/L MUREAV 469,135,2000
DNA inhibition mouse fibroblast 300 µmol/L JTEHD6 15,237,1985
unscheduled DNA synthesis human fibroblast 100 µmol/L DCTODJ 4,185,1981
mutation in microorganisms Salmonella typhimurium 2 µmol/plate (+enzymatic activation step) EESADV 9,92,1985
mutation in microorganisms Saccharomyes cerevisiae 80 mmol/L (+/-enzymatic activation step) TECSDY 13,103,1986
micronucleus test human fibroblast 1 µmol/L/24 hour MUREAV 490,99,2001
gene conversion and mitotic recombination Saccharomyes cerevisiae 40 mmol/L TECSDY 13,103,1986
other mutation test systems Bacillus subtilis 30 µmol/L BECTA6 43,254,1989
phage inhibition capacity Escherichia coli 500 µmol/L ENMUDM 6,59,1984
sister chromatid exchange hamster fibroblast 1 mg/L MUREAV 104,141,1982
specific locus test hamster ovary 0.5 mmol/L/48 hour MUREAV 513,135,2002
sperm morphology oral
rat 		45,750 µg/kg/26 week- continuous GISAAA 50(7),31,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 44,600 µg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear 		JTSCDR 1(2),1,1976
intraperitoneal
mouse 		lowest published toxic dose: 30 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTSCDR 1(2),1,1976
intraperitoneal
mouse 		lowest published toxic dose: 59,500 µg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JTSCDR 1(2),1,1976
intraperitoneal
mouse 		lowest published toxic dose: 59,500 µg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) JTSCDR 1(2),1,1976
intratesticular
rat 		lowest published toxic dose: 12,668 µg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JRPFA4 7,21,1964
intravenous
hamster 		lowest published toxic dose: 8 mg/kg (8 day pregnant) Reproductive: Other developmental abnormalities VCVN5* -,301,1989
oral
mouse 		lowest published toxic dose: 84 gm/kg (12 week male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) TXCYAC 116,39,1997
oral
mouse 		lowest published toxic dose: 33,600 mg/kg (12 week prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		TXCYAC 116,39,1997
subcutaneous
mouse 		lowest published toxic dose: 450 mg/kg (1-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 12,198,1975
subcutaneous
mouse 		lowest published toxic dose: 12,668 µg/kg (30 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 31,500 µg/m3/2 hour N/R 85GMAT -,39,1982
inhalation
mouse 		lethal concentration (50 percent kill): 31.5 mg/m3 N/R VCVN5* -,301,1993
intramuscular
mouse 		lethal dose (50 percent kill): 40 mg/kg N/R 85GMAT -,39,1982
intraperitoneal
guinea pig 		lowest published lethal dose: 200 mg/kg N/R AEHLAU 11,201,1965
intraperitoneal
mouse 		lethal dose (50 percent kill): 143 mg/kg N/R COREAF 256,1043,1963
intravenous
mouse 		lowest published lethal dose: 400 mg/kg N/R AQMOAC #70-15,1970
intravenous
rabbit 		lowest published lethal dose: 288 mg/kg N/R EQSSDX 1,1,1975
oral
rat 		lethal dose (50 percent kill): 440 mg/kg N/R VCVN5* -,301,1993
subcutaneous
mouse 		lowest published lethal dose: 800 mg/kg N/R AQMOAC #70-15,1970
subcutaneous
mouse 		lethal dose (50 percent kill): 7.8 mg/kg N/R VCVN5* -,301,1993
skin
guinea pig 		lowest published lethal dose: 202 mg/kg N/R AEHLAU 11,201,1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 450 mg/kg/3 day- intermittent Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		WDZAEK 6,205,1992
oral
chicken 		lowest published toxic dose: 4.9 mg/kg/28 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JAPTO* 22,161,2002
oral
mouse 		lowest published toxic dose: 33,600 mg/kg/12 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		TXCYAC 116,39,1997


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg(Cr)/m3 DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 49,49,1990
TOXICOLOGY REVIEW
85DHAX Cr,22,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg(Cr)/m3 DTLVS* 3,35,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 41,50-204.50,1994


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84456;
Number of Industries 2;
Total Number of Facilities 32;
Number of Occupations 3;
Total Number of Employees Exposed 268
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84456;
Number of Industries 4;
Total Number of Facilities 338;
Number of Occupations 9;
Total Number of Employees Exposed 3,273;
Total Number of Female Employees Exposed 1,706


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for production of solutions of basic chlorides and as a catalyst
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CARYAB Caryologia. (Via G. LaPira 4, 50121 Florence, Italy) V.1- 1948-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

Used for production of solutions of basic chlorides and as a catalyst

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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