The Registry of Toxic Effects of Chemical Substances

Chromium (III) oxide (2:3)

RTECS #: GB6475000

CAS #: 1308-38-9

UPDATE: May 2004 MW: 152.00 MF: Cr2O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Anhydride chromique (French)
  2. Chromium oxide (Cr8O12)
  3. Casalis Green
  4. Chrome Oxide Green GN - M
  5. Chromia
  6. Chromium Oxide X1134
  7. C.I. 77288
  8. C.I. Pigment Green 17
  9. Dichromium trioxide
  10. 11661 Green
  11. Green Chrome Oxide
  12. Green chromic oxide
  13. Green chromium oxide
  14. Green cinnabar
  15. Green Oxide of Chromium
  1. Green oxide of chromium OC - 31
  2. Levanox Green GA
  3. P 106F10
  4. PK 5304
  5. Pure Chromium Oxide Green 59
  6. Chrome Green
  7. Chrome ochre
  8. Chrome Oxide Green BX
  9. Chromic Acid Green
  10. Chromic oxide
  11. Chromium (3+) oxide
  12. Chromium Oxide Green
  13. Chromium Oxide Pigment
  14. Chromium sesquioxide
  15. OKhP1


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 10 mmol/L MUREAV 77,109,1980
mutation in microorganisms Salmonella typhimurium 10 µg/plate (+enzymatic activation step) DCTODJ 4,185,1981
mutation in mammalian somatic cells hamster lung 50 mg/L MUREAV 169,159,1986
other mutation test systems hamster lung 100 mg/L MUREAV 169,159,1986
sister chromatid exchange hamster lung 34 mg/L CRNGDP 4,605,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intrapleural
rat 		lowest published toxic dose: 45 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application 		VOONAW 13(11),57,1967
intraperitoneal
rat 		lowest published toxic dose: 90 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Kidney tumors 		VOONAW 13(11),57,1967
intratracheal
rat 		lowest published toxic dose: 90 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application 		VOONAW 13(11),57,1967


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 4.2 mg/m3/24 hour/17 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema 		VCVN5* -,303,1989
inhalation
rat 		lowest published toxic concentration: 150 mg/m3/4 hour/6 week- intermittent Lung, Thorax, or Respiration: Emphysema

Blood: Pigmented or nucleated red blood cells

Blood: Changes in leukocyte (WBC) count 		TPKVAL 7,162,1965
inhalation
rat 		lowest published toxic concentration: 15 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Endocrine: Changes in thyroid weight 		TOSCF2 52,278,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg(Cr)/m3 DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 49,49,1990
TOXICOLOGY REVIEW
FCTXAV 9,105,1971
TOXICOLOGY REVIEW
85DHAX Cr,22,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg(Cr)/m3 DTLVS* 3,35,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 41,50-204.50,1994


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2273;
Number of Industries 49;
Total Number of Facilities 3,141;
Number of Occupations 66;
Total Number of Employees Exposed 42,380
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0962;
Number of Industries 7;
Total Number of Facilities 288;
Number of Occupations 26;
Total Number of Employees Exposed 8,322
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0962;
Number of Industries 87;
Total Number of Facilities 7,613;
Number of Occupations 56;
Total Number of Employees Exposed 88,897;
Total Number of Female Employees Exposed 11,984


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a pigment, in manufacture of CHROMIUM and its alloys, and as a catalyst
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-

Used as a pigment, in manufacture of CHROMIUM and its alloys, and as a catalyst

NIOSH PROFILE (INORGANIC CHROMIUM COMPOUNDS), SRC, 2/82

RTECS Compound Description:
   Tumorigen
   Mutagen

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