The Registry of Toxic Effects of Chemical Substances

Citric acid, trisodium salt

RTECS #: GE8300000

CAS #: 68-04-2

UPDATE: October 1997 MW: 258.08 MF: C6H5O7•3Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. NIOSH DOCUMENTATION AND SURVEILLANCE:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. Citnatin
  2. Citreme
  3. Natrocitral
  4. Citrosodine
  1. Citrosodna
  2. 1,2,3 - Propanetricarboxylic acid, 2 - hydroxy - , trisodium salt (9CI)
  3. Trisodium citrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,364 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands 		JPETAB 94,65,1948
intraperitoneal
rat 		lethal dose (50 percent kill): 1,548 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands 		JPETAB 94,65,1948
intravenous
mouse 		lethal dose (50 percent kill): 170 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands 		JPETAB 94,65,1948
intravenous
rabbit 		lethal dose (50 percent kill): 449 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands 		JPETAB 94,65,1948


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 68905;
Number of Industries 165;
Total Number of Facilities 38,675;
Number of Occupations 97;
Total Number of Employees Exposed 200,416
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: E0257;
Number of Industries 1;
Total Number of Facilities 403;
Number of Occupations 5;
Total Number of Employees Exposed 4,029;
Total Number of Female Employees Exposed 2,015
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 68905;
Number of Industries 96;
Total Number of Facilities 13,473;
Number of Occupations 105;
Total Number of Employees Exposed 301,805;
Total Number of Female Employees Exposed 163,142


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in photography, as a sequestering agent to remove trace metals, as an emulsifier
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-

Used in photography, as a sequestering agent to remove trace metals, as an emulsifier

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