The Registry of Toxic Effects of Chemical Substances

Cobalt (II) nitrate (1:2)

RTECS #: GG1109000

CAS #: 10141-05-6

UPDATE: May 2005 MW: 182.95 MF: N2O6•Co


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Cobalt bis (nitrate)
  2. Cobalt dinitrate
  3. Cobalt nitrate
  4. Cobalt (2+) nitrate
  1. Cobalt (II) nitrate
  2. Nitric acid, cobalt (2+) salt
  3. Cobaltous nitrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratesticular
rat 		lowest published toxic dose: 14,636 µg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964
subcutaneous
mouse 		lowest published toxic dose: 14,636 µg/kg (30 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rabbit 		lowest published toxic dose: 4,530 µg/kg/5 day- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		COREAF 236,1387,1953


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
pigeon 		lowest published lethal dose: 50 mg/kg N/R HBAMAK 4,1289,1935
oral
rat 		lethal dose (50 percent kill): 434 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 20,311,1982
oral
rat 		lethal dose (50 percent kill): 434 mg/kg Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Hemorrhage 		VCVN5* -,453,1989
oral
rabbit 		lowest published lethal dose: 250 mg/kg N/R EQSSDX 1,1,1975
subcutaneous
frog 		lowest published lethal dose: 150 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
rabbit 		lowest published lethal dose: 75 mg/kg N/R EQSSDX 1,1,1975
unreported route
rabbit 		lowest published toxic dose: 0.2 mg/kg Vascular: BP lowering not characterized in autonomic section VCVN5* -,456,1989
unreported route
rabbit 		lowest published lethal dose: 60 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Behavioral: Tetany 		VCVN5* -,456,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 140 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes in urine composition 		ETOPFR 17,159,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 52,363,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 52,363,1991


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84330;
Number of Industries 18;
Total Number of Facilities 1,152;
Number of Occupations 15;
Total Number of Employees Exposed 6,182
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84330;
Number of Industries 18;
Total Number of Facilities 732;
Number of Occupations 24;
Total Number of Employees Exposed 16,243;
Total Number of Female Employees Exposed 4,029


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in sympathetic inks, pigments preparation of catalysts, additive to soils, animal feed

NIOSH PROFILE (COBALT and ITS COMPOUNDS), SRI, 10/77

RTECS Compound Description:
   Tumorigen
   Reproductive Effector

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