The Registry of Toxic Effects of Chemical Substances

Cobalt (II) sulfate (1:1) , heptahydrate

RTECS #: GG3200000

CAS #: 10026-24-1

UPDATE: July 2002 MW: 281.13 MF: CoO4S•7H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Cobalt monosulfate heptahydrate
  2. Cobalt sulfate heptahydrate
  3. Cobalt (II) sulphate heptahydrate
  1. Cobaltous sulfate heptahydrate
  2. Sulfuric acid, cobalt (2+) salt (1:1) , heptahydrate (8CI,9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
micronucleus test hamster embryo 1 mg/L MUREAV 392,61,1997


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 30 mg/m3/6 hour (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		FAATDF 15,357,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lethal dose (50 percent kill): 320 mg/kg N/R FATOBP 13,94,1978
intravenous
dog 		lowest published lethal dose: 16,200 µg/kg N/R EQSSDX 1,1,1975
oral
rat 		lethal dose (50 percent kill): 582 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea 		ATDAEI 1,688,1992


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 30 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Endocrine: Effect on menstrual cycle

Related to Chronic Data: Changes in testicular weight 		FAATDF 15,357,1990
inhalation
rat 		lowest published toxic concentration: 91 mg/m3/6 hour/16 day- intermittent Eye: Chromodacryorrhea

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Endocrine: Changes in thymus weight 		NTPTR* NIH-91-3124
inhalation
rat 		lowest published toxic concentration: 18 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Pigmented or nucleated red blood cells 		NTPTR* NIH-91-3124


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2377;
Number of Industries 5;
Total Number of Facilities 126;
Number of Occupations 5;
Total Number of Employees Exposed 3,264;
Total Number of Female Employees Exposed 1,853


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NTP Toxicity studies, RPT# TOX-05, October 2000


REFERENCES:

CODEN
REFERENCE
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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