The Registry of Toxic Effects of Chemical Substances

Cobalt, di - mu - carbonylhexacarbonyldi - , (Co - Co)

RTECS #: GG0300000

CAS #: 10210-68-1

UPDATE: November 2004 MW: 341.94 MF: C8Co2O8


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Cobalt carbonyl
  2. Cobalt carbonyl (ACGIH)
  3. Cobalt octacarbonyl
  4. Cobalt tetracarbonyl
  5. Cobalt tetracarbonyl dimer
  1. Di - mu - carbonylhexacarbonyldicobalt
  2. Dicobalt carbonyl
  3. Dicobalt octacarbonyl
  4. Octacarbonyldicobalt


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 26,900 µg/m3/2 hour Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea 		VRDEA5 (2),101,1969
inhalation
rat 		lethal concentration (50 percent kill): 165 mg/m3 Lung, Thorax, or Respiration: Acute pulmonary edema VRDEA5 (2),101,1969
oral
mouse 		lethal dose (50 percent kill): 378 mg/kg N/R GISAAA 38(1),97,1973
oral
rat 		lethal dose (50 percent kill): 754 mg/kg N/R GISAAA 38(1),97,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 3,468 mg/kg/23 day- intermittent Cardiac: Cardiomyopathy including infarction

Endocrine: Hyperglycemia

Blood: Pigmented or nucleated red blood cells 		GISAAA 38(1),97,1973


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Co)/m3 DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 52,363,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 52,363,1991


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.01 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(Co)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.01 mg/m3, short term exposure limit 0.02 mg/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 mg(Co)/m3, 2B Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(Co)/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 mg(Co)/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 mg(Co)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO COBALT CARBONYL-air 10 hour time-weighted average 0.1 mg/m3 NIOSH* DHHS #95-121,1995


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
OSHA ANALYTICAL METHOD #ID-125G


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VRDEA5 Vrachebnoe Delo. Medical Practice. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1918-

RTECS Compound Description:
   Tumorigen

ALT CAS #: 90043-99-5
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