The Registry of Toxic Effects of Chemical Substances

m - Cresol, 4,4' - thiobis (6 - tert - butyl -

RTECS #: GP3150000

CAS #: 96-69-5

UPDATE: February 2005 MW: 358.58 MF: C22H30O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1' - Thiobis (2 - methyl - 4 - hydroxy - 5 - tert - butylbenzene)
  2. 4,4' - Thiobis
  3. 4,4' - Thiobis (2 - (1,1 - dimethylethyl) - 5 - methylphenol)
  4. 4,4' - Thiobis (2 - tert - butyl - 5 - methylphenol)
  5. 4,4' - Thiobis (3 - methyl - 6 - tert - butylphenol)
  6. 4,4' - Thiobis (6 - tert - butyl - 3 - methylphenol)
  7. 4,4' - Thiobis (6 - tert - butyl - m - cresol)
  8. 4,4' - Thiobis (6 - tert - butyl - m - cresol) (ACGIH,OSHA)
  9. AO 4
  10. Antage Crystal
  11. Antioxidant AO
  12. Antioxidant TMB 6
  13. Bis (3 - tert - butyl - 4 - hydroxy - 6 - methylphenyl) sulfide
  14. Bis (4 - hydroxy - 5 - tert - butyl - 2 - methylphenyl) sulfide
  15. Disperse MB - 61
  16. Nocrac 300
  1. Nonflex BPS
  2. Phenol, 4,4' - thiobis (2 - (1,1 - dimethylethyl) - 5 - methyl - (9CI)
  3. Santonox
  4. Santonox BM
  5. Santonox R
  6. Santowhite crystals
  7. Santox
  8. Sumilizer WX
  9. Sumilizer WX - R
  10. Thioalkofen BM 4
  11. Thioalkofen BMCH
  12. Thioalkofen MBCH
  13. Thioalkophene BM - 4
  14. USAF B - 15
  15. Yoshinox S
  16. Yoshinox SR


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 50 mg/kg N/R NTIS** AD277-689
oral
rat 		lethal dose (50 percent kill): 2,345 mg/kg N/R IPSTB3 3,93,1976
oral
rabbit 		lethal dose (50 percent kill): 3,200 mg/kg N/R IPSTB3 3,93,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		FAATDF 10,691,1988
oral
mouse 		lowest published toxic dose: 5,915 mg/kg/13 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight 		NTPTR* NTP-TR-435,1994
oral
rat 		lowest published toxic dose: 5,475 mg/kg/15 day- continuous Gastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in leukocyte (WBC) count 		NTPTR* NTP-TR-435,1994
oral
rat 		lowest published toxic dose: 15,015 mg/kg/13 week- continuous Liver: Changes in liver weight

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		NTPTR* NTP-TR-435,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - DENMARK time-weighted average 10 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL), dust-air time-weighted average 10 mg/m3 NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL)-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84755;
Number of Industries 51;
Total Number of Facilities 4,402;
Number of Occupations 47;
Total Number of Employees Exposed 36,695
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84755;
Number of Industries 10;
Total Number of Facilities 1,286;
Number of Occupations 11;
Total Number of Employees Exposed 12,349;
Total Number of Female Employees Exposed 2,177


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antioxidant in rubber and plastics industry
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9277;8EHQ-0892-9283
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

Used as an antioxidant in rubber and plastics industry

RTECS Compound Description:
   Tumorigen

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