The Registry of Toxic Effects of Chemical Substances

Crotonaldehyde

RTECS #: GP9499000

CAS #: 4170-30-3

UPDATE: May 2005 MW: 70.10 MF: C4H6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Formylpropene
  2. 2 - Butenal
  3. 2 - Butenal (9CI)
  4. 2 - Butenaldehyde
  5. Crotonal
  6. Crotonaldehyde (ACGIH:OSHA)
  1. Crotonic aldehyde
  2. Krotonaldehyd (Czech)
  3. Methylpropenal
  4. RCRA waste number U053
  5. beta - Methylacrolein


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 1,600 µg/L EMMUEG 10(Suppl 10),1,1987
DNA adduct cattle other cell types 0.4 mmol/plate/96 hour CRTOEC 14,423,2001
DNA adduct human fibroblast 100 µmol/L CRNGDP 12,1483,1991
DNA adduct mammal (species unspecified) lymphocyte 21,500 mg/L/16 hour CNREA8 44,990,1984
mutation in microorganisms Escherichia coli 75 nmol/plate MUREAV 516,81,2002
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) EMMUEG 14,146,1989
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
sister chromatid exchange hamster ovary 500 µg/L EMMUEG 10(Suppl 10),1,1987
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster 		3,500 ppm ENMUDM 7,677,1985
heritable translocation test parenteral
Drosophila melanogaster 		3,500 ppm ENMUDM 7,677,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 2,664 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		CNREA8 46,1285,1986


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 25 mg/m3 Olfaction: Other olfaction effects VCVGK* -,390,1984
inhalation
human 		lowest published toxic concentration: 40 mg/m3/10S Eye: Conjunctiva irritation VCVGK* -,390,1984
inhalation
human 		lowest published toxic concentration: 8 mg/m3 Eye: Conjunctiva irritation VCVGK* -,390,1984
inhalation
mouse 		lethal concentration (50 percent kill): 580 mg/m3/2 hour N/R GTPZAB 26(8),53,1982
inhalation
rat 		lethal concentration (50 percent kill): 200 mg/m3/2 hour N/R GTPZAB 26(8),53,1982
inhalation
rat 		lethal concentration (50 percent kill): 9,600 mg/m3/5 minute N/R VCVGK* -,390,1984
inhalation
rat 		lethal concentration (50 percent kill): 4,800 mg/m3/10 minute N/R VCVGK* -,390,1984
inhalation
rat 		lethal concentration (50 percent kill): 2,400 mg/m3/15 minute N/R VCVGK* -,390,1984
inhalation
rat 		lethal concentration (50 percent kill): 1,700 mg/m3/30 minute N/R VCVGK* -,390,1984
inhalation
rat 		lethal concentration (50 percent kill): 1,100 mg/m3/60 minute N/R VCVGK* -,390,1984
inhalation
rat 		lethal concentration (50 percent kill): 300 mg/m3/4 hour N/R VCVGK* -,390,1984
inhalation
rat 		lowest published toxic concentration: 87 mg/kg/4 hour Cardiac: Other changes

Blood: Other changes 		TOLED5 135,S143,2002
intravenous
cat 		lowest published lethal dose: 30 mg/kg Blood: Other changes APTOA6 8,275,1952
oral
mouse 		lethal dose (50 percent kill): 104 mg/kg N/R GTPZAB 26(8),53,1982
oral
rat 		lethal dose (50 percent kill): 80 mg/kg Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Body temperature decrease 		GISAAA 62(3),3,1997
skin
guinea pig 		lethal dose (50 percent kill): 30 µL/kg N/R JIHTAB 26,269,1944
skin
rabbit 		lethal dose (50 percent kill): 380 µL/kg N/R UCDS** 4/21/1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/7 hour/8 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other proteins 		GTPZAB 18(6),55,1974
intratracheal
rat 		lowest published toxic dose: 5 mg/m3/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,390,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.3 ppm (skin) DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 63,373,1995
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 63,373,1995
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 63,373,1995
TOXICOLOGY REVIEW
MUREAV 544,115,2003
TOXICOLOGY REVIEW
MUREAV 567,347,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 ppm (6 mg/m3) DTLVS* 3,62,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2 ppm (6 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2 ppm (6 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2 ppm (6 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2 ppm (6 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (5.7 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (6 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 2 ppm (6 mg/m3), short term exposure limit 6 ppm (17 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit - GERMANY Skin, Carcinogen, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit - POLAND time-weighted average 6 mg/m3, short term exposure limit 12 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (6 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 2 ppm (6 mg/m3), short term exposure limit 6 ppm (18 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 0.3 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 0.3 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6304;
Number of Industries 2;
Total Number of Facilities 6;
Number of Occupations 2;
Total Number of Employees Exposed 387;
Total Number of Female Employees Exposed 17


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a warning agent in fuel gases and gas line leaks, as solvent, in chemical warfare
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
NIOSH Analytical Method, 1994: Crotonaldehyde, 3516


REFERENCES:

CODEN
REFERENCE
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a warning agent in fuel gases and gas line leaks, as solvent, in chemical warfare

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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