The Registry of Toxic Effects of Chemical Substances

Crotonic acid, 2 (or 4) - (1 - methylheptyl) - 4,6 (or 2,6) - dinitrophenyl ester

RTECS #: GQ5775000

CAS #: 39300-45-3

UPDATE: November 2003 MW: 364.44 MF: C18H24N2O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Arathane
  2. CR 1639
  3. 2 - Butenoic acid, 2 - (or 4) - isooctyl - 4,6 (or 2,6) - dinitrophenyl ester (9CI)
  4. Caprane
  5. Capryldinitrophenyl crotonate
  6. 2 - Capryl - 4,6 - dinitrophenyl crotonate
  7. Crotonate de 2,4 - dinitro 6 - (1 - methyl - heptyl) - phenyle (French)
  8. DPC (pesticide)
  9. ENT 24727
  10. Karathane
  11. Karathane 25
  12. Karathane FN 57
  13. Karathane WD
  14. (6 - (1 - Methyl - heptyl) - 2,4 - dinitro - fenyl) - crotonaat (Dutch)
  15. 2 - (1 - Methylheptyl) - 4,6 - dinitrofenylester kyseliny krotonove (Czech)
  16. (6 - (1 - Methyl - heptyl) - 2,3 - dinitro - phenyl) - crotonat (German)
  17. 2 - (1 - Methylheptyl) - 4,6 - dinitrophenyl crotonate
  1. (6 - (1 - Metil - epitl) - 2,4 - dinitro - fenil) - crotonato (Italian)
  2. Mildex
  3. Crotonic acid 2,4 - dinitro - 6 - (1 - methylheptyl) phenyl ester
  4. Crotonic acid 2,4 - dinitro - 6 - (2 - octyl) phenyl ester
  5. Crotothane
  6. 4,6 - Dinitro - 2 - caprylphenyl crotonate
  7. 4,6 - Dinitro - 2 - (2 - capryl) phenyl crotonate
  8. 2,4 - Dinitro - 6 - (1 - methylheptyl) - phenylcrotonat (German)
  9. Dinitro (1 - methylheptyl) phenyl crotonate
  10. 2,4 - Dinitro - 6 - (1 - methylheptyl) phenyl crotonate
  11. 4,6 - Dinitro - 2 - (1 - methylheptyl) phenyl crotonate
  12. 2,4 - Dinitro - 6 - (2 - octyl) phenyl crotonate
  13. Dinocap
  14. Dinokap
  15. Dinokapu (Polish)
  16. Phenol, 2 - (1 - methylheptyl) - 4,6 - dinitro - , crotonate (ester)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 500 µg/plate (+enzymatic activation step) MUREAV 116,185,1983
mutation in microorganisms Saccharomyes cerevisiae 5 ppm (-enzymatic activation step) RSTUDV 6,161,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
hamster 		lowest published toxic dose: 400 mg/kg (8-11 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TCMUD8 6,33,1986
oral
hamster 		lowest published toxic dose: 800 mg/kg (7-14 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear TJADAB 39,515,1989
oral
hamster 		lowest published toxic dose: 400 mg/kg (7-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 39,515,1989
oral
hamster 		lowest published toxic dose: 800 mg/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		TJADAB 39,515,1989
oral
mouse 		lowest published toxic dose: 120 mg/kg (7-16 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		TCMUD8 6,33,1986
oral
mouse 		lowest published toxic dose: 250 mg/kg (7-16 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		TCMUD8 6,33,1986
oral
mouse 		lowest published toxic dose: 50 mg/kg (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TCMUD8 6,375,1986
oral
mouse 		lowest published toxic dose: 100 mg/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Hepatobiliary system 		TCMUD8 6,375,1986
oral
mouse 		lowest published toxic dose: 200 mg/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TCMUD8 6,375,1986
oral
mouse 		lowest published toxic dose: 550 mg/kg (1-21 day pregnant) Reproductive: Effects on newborn: Stillbirth HBPTO* 2,1230,2001
oral
mouse 		lowest published toxic dose: 264 mg/kg (1-21 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Other developmental abnormalities 		HBPTO* 2,1230,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 10 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Blood: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 360 mg/m3/4 hour N/R PEMNDP 9,303,1991
inhalation
rat 		lethal concentration (50 percent kill): 3,000,000 mg/m3 N/R HBPTO* 2,1229,2001
intravenous
rat 		lethal dose (50 percent kill): 2.5 mg/kg N/R HBPTO* 2,1228,2001
oral
dog 		lethal dose (50 percent kill): 100 mg/kg N/R SPEADM 78-1,25,1978
oral
mouse 		lethal dose (50 percent kill): 49,500 µg/kg N/R BCTKAG 8,373,1975
oral
rat 		lethal dose (50 percent kill): 766 mg/kg Liver: Other changes KHZDAN 18,379,1975
oral
rat 		lethal dose (50 percent kill): 980 mg/kg N/R HBPTO* 2,1229,2001
oral
rabbit 		lethal dose (50 percent kill): 3 gm/kg N/R BCTKAG 8,373,1975
skin
rabbit 		lethal dose (50 percent kill): 9,400 mg/kg N/R SPEADM 78-1,25,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
duck 		lowest published toxic dose: 123 mg/kg/7 week- continuous Eye: Other eye effects AIPTAK 119,31,1959
oral
dog 		lowest published toxic dose: 9,125 mg/kg/1 year- continuous Liver: Other changes

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIPTAK 119,31,1959
oral
dog 		lowest published toxic dose: 562.5 mg/kg/90 day- continuous Liver: Hepatitis (hepatocellular necrosis), zonal HBPTO* 2,1228,2001
oral
dog 		lowest published toxic dose: 1,095 mg/kg/2 year- continuous Eye: Retinal changes pigmentary deposition, retinitis, other) HBPTO* 2,1229,2001
oral
mouse 		lowest published toxic dose: 300 mg/kg/12 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Increased immune response 		TXCYAC 75,235,1992
oral
mouse 		lowest published toxic dose: 105 mg/kg/7 day- intermittent Immunological Including Allergic: Decrease in humoral immune response TXCYAC 75,235,1992
oral
mouse 		lowest published toxic dose: 1,680 mg/kg/28 day- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		HBPTO* 2,1228,2001
oral
mouse 		lowest published toxic dose: 9,855 mg/kg/78 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		HBPTO* 2,1229,2001
oral
mouse 		lowest published toxic dose: 175 mg/kg/7 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in cellular immune response 		HBPTO* 2,1230,2001
oral
rat 		lowest published toxic dose: 27,300 mg/kg/26 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIPTAK 119,31,1959
oral
rat 		lowest published toxic dose: 2,920 gm/kg/2 year- continuous Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		BCTKAG 11,111,1978
oral
rat 		lowest published toxic dose: 1,700 mg/kg/90 day- intermittent Liver: Changes in liver weight

Endocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		BCTKAG 9,217,1976
oral
rat 		lowest published toxic dose: 91.25 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		HBPTO* 2,1229,2001
oral
rat 		lowest published toxic dose: 91.25 gm/kg/2 year- continuous Endocrine: Other changes HBPTO* 2,1229,2001
oral
rabbit 		lowest published toxic dose: 2,700 mg/kg/90 day- continuous Gastrointestinal: Other changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Other changes 		HBPTO* 2,1228,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,176,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued.
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used for control of powdery mildew diseases and certain species of mites

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 12684-10-5
 Click Here for Additional Information about RTECS