The Registry of Toxic Effects of Chemical Substances

Cumene

RTECS #: GR8575000

CAS #: 98-82-8

UPDATE: November 2004 MW: 120.21 MF: C9H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Cumeen (Dutch)
  2. Benzene, isopropyl
  3. Benzene, (1 - methylethyl) - (9CI)
  4. 2 - Fenilpropano (Italian)
  5. 2 - Fenyl - propaan (Dutch)
  6. Isopropylbenzeen (Dutch)
  7. Isopropilbenzene (Italian)
  8. Isopropyl benzene
  1. Isopropylbenzol
  2. Isopropyl - benzol (German)
  3. (1 - Methylethyl) benzene
  4. 2 - Phenylpropane
  5. RCRA waste number U055
  6. Cumene (ACGIH:OSHA)
  7. Cumol
  8. Propane, 2 - phenyl


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		86 mg mild AMIHAB 14,387,1956
eye
rabbit 		500 mg/24 hour mild 85JCAE -,33,1986
skin
rabbit 		10 mg/24 hour open irritation test mild AMIHBC 4,119,1951
skin
rabbit 		100 mg/24 hour moderate 85JCAE -,33,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 100 µg/plate/3 hour (-enzymatic activation step) FCTOD7 40,1,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 200 ppm Behavioral: Somnolence (general depressed activity)

Behavioral: Antipsychotic

Behavioral: Irritability 		TGNCDL 2,39,1961
inhalation
mouse 		lethal concentration (50 percent kill): 10 gm/m3/7 hour Liver: Multiple effects

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in spleen 		JIHTAB 26,264,1944
inhalation
mouse 		lethal concentration (50 percent kill): 15,300 mg/m3/2 hour N/R VCVGH* -,169,1990
inhalation
mouse 		lethal concentration (50 percent kill): 10,000 mg/m3/7 hour N/R VCVGH* -,169,1990
inhalation
mouse 		lowest published toxic concentration: 5,150 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,169,1990
inhalation
rat 		lowest published lethal concentration: 8,000 ppm/4 hour N/R AMIHBC 4,119,1951
inhalation
rat 		lethal concentration (50 percent kill): 39,000 mg/m3/4 hour N/R VCVGH* -,169,1990
oral
mouse 		lethal dose (50 percent kill): 12,750 mg/kg N/R GISAAA 36(9),18,1971
oral
rat 		lethal dose (50 percent kill): 1,400 mg/kg Gastrointestinal: Gastritis AMIHAB 14,387,1956
oral
rat 		lethal dose (50 percent kill): 2.9 gm/kg Behavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory obstruction 		VCVGH* -,169,1990
skin
rabbit 		lethal dose (50 percent kill): 12,300 µL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 2,000 mg/m3/14 week- continuous Behavioral: Somnolence (general depressed activity) VCVGH* -,170,1990
inhalation
rat 		lowest published toxic concentration: 1,200 ppm/6 hour/13 week- intermittent Eye: Other eye effects

Behavioral: Change in motor activity (specific assay)

Blood: Pigmented or nucleated red blood cells 		NTIS** OTS0522342
inhalation
rabbit 		lowest published toxic concentration: 10,000 mg/m3/2 hour/24 week- intermittent Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage

Blood: Changes in leukocyte (WBC) count 		VCVGH* -,170,1990
oral
rabbit 		lowest published toxic dose: 89,628 mg/kg/194 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight VCVGH* -,169,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (245 mg/m3) (skin) DTLWS* 3,14,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (245 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (245 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (245 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (245 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (245 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (245 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (246 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (120 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (245 mg/m3), short term exposure limit 75 ppm (370 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (245 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 50 ppm (245 mg/m3), Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 80 mg/m3, short term exposure limit 100 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 100 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (245 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 350 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 50 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 25 ppm (120 mg/m3), KTV 35 ppm (170 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (245 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (125 mg/m3), short term exposure limit 75 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CUMENE-air 10 hour time-weighted average 50 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 20850;
Number of Industries 2;
Total Number of Facilities 24;
Number of Occupations 8;
Total Number of Employees Exposed 669
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 20850;
Number of Industries 15;
Total Number of Facilities 1,199;
Number of Occupations 24;
Total Number of Employees Exposed 14,268;
Total Number of Female Employees Exposed 2,760


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of PHENOL and ACETONE and as a paint thinner
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501
NTP Carcinogenesis studies; on test (prechronic studies), October 2000


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago, National Assoc. of Mutual Casualty Companies, 1961
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in production of PHENOL and ACETONE and as a paint thinner

Top 50 chemical production: 4.57 billions lbs in 1992, 4.17 billions in 1991

NIOSH PROFILE (ARENES), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

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