The Registry of Toxic Effects of Chemical Substances

Cyanamide

RTECS #: GS5950000

CAS #: 420-04-2

UPDATE: May 2005 MW: 42.05 MF: CH2N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Alzogur
  2. Amidocyanogen
  3. Carbamonitrile
  4. Carbimide
  5. Carbodiimide
  6. Cyanamide (ACGIH)
  7. Cyanoamine
  1. N - Cyanoamine
  2. Cyanogenamide
  3. Cyanogen nitride
  4. Hydrogen cyanamide
  5. TsAKS
  6. USAF EK - 1995


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 2,450 mg/kg (70 day male/2 week prior to copulation-2 week pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Other measures of fertility 		PHTOEH 61,20,1987
oral
rat 		lowest published toxic dose: 1,750 mg/kg (70 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		PHTOEH 61,20,1987
oral
rat 		lowest published toxic dose: 2,600 mg/kg (70 day male/2 week prior to copulation-3 week pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects 		PHTOEH 61,20,1987
oral
rat 		lowest published toxic dose: 208 mg/kg (70 day male/2 week prior to copulation-3 week pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		PHTOEH 61,20,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 86 mg/m3/4 hour N/R 85GMAT -,40,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat 		lowest published lethal dose: 200 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Coma

Gastrointestinal: Changes in structure or function of salivary glands 		PSEBAA 54,254,1943
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		EKFAE9 59,38,1996
intraperitoneal
rat 		lowest published toxic dose: 25 gm/kg Taste: Change in function PSCHDL 167,130,2003
intravenous
rat 		lethal dose (50 percent kill): 56 mg/kg N/R 85GMAT -,40,1982
oral
cat 		lethal dose (50 percent kill): 100 mg/kg N/R 85GMAT -,40,1982
oral
mouse 		lethal dose (50 percent kill): 388 mg/kg N/R 85GMAT -,40,1982
oral
rat 		lethal dose (50 percent kill): 125 mg/kg N/R 85KYAH 11,418,1989
oral
rabbit 		lethal dose (50 percent kill): 150 mg/kg N/R 85GMAT -,40,1982
skin
rat 		lethal dose (50 percent kill): 84 mg/kg N/R 85GMAT -,40,1982
skin
rabbit 		lethal dose (50 percent kill): 590 mg/kg N/R 34ZIAG -,190,1969
unreported route
rat 		lethal dose (50 percent kill): 280 mg/kg N/R 34ZIAG -,190,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg/m3 DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,373,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (11 mg/m3) (skin) DTLVS* 3,130,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 2 mg/m3, short term exposure limit 4 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 2 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 2 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYANAMIDE-air 10 hour time-weighted average 2 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 20930;
Number of Industries 2;
Total Number of Facilities 76;
Number of Occupations 2;
Total Number of Employees Exposed 962
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 20930;
Number of Industries 2;
Total Number of Facilities 19;
Number of Occupations 2;
Total Number of Employees Exposed 2,564;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Reproductive Effector

ALT CAS #: 65931-45-5
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