The Registry of Toxic Effects of Chemical Substances

Cyanogen (C2N2)

RTECS #: GT1925000

CAS #: 460-19-5

UPDATE: November 2004 MW: 52.04 MF: C2N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Carbon nitride
  2. Cyanogen
  3. Cyanogen (ACGIH:OSHA)
  4. Cyanogene (French)
  5. Dicyan
  6. Dicyanogen
  7. Ethanedinitrile (9CI)
  1. Nitriloacetonitrile
  2. Oxalic acid dinitrile
  3. Oxalic nitrile
  4. Oxalonitrile
  5. Oxalyl cyanide
  6. RCRA waste number P031


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		16 ppm/6 minute N/R AIHAAP 21,121,1960


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 16 ppm Eye: Conjunctiva irritation

Olfaction: Change in olfactory nerve 		AIHAAP 21,121,1960
inhalation
rat 		lethal concentration (50 percent kill): 350 ppm/1 hour Lung, Thorax, or Respiration: Respiratory obstruction

Eye: Lacrimation

Behavioral: Somnolence (general depressed activity) 		AIHAAP 21,121,1960
subcutaneous
dog 		lowest published lethal dose: 15 mg/kg N/R AIPTAK 3,77,1897
subcutaneous
frog 		lowest published lethal dose: 43 mg/kg N/R AIPTAK 3,77,1897
subcutaneous
pigeon 		lowest published lethal dose: 9 mg/kg Behavioral: Convulsions or effect on seizure threshold AIPTAK 3,77,1897
subcutaneous
rabbit 		lowest published lethal dose: 13 mg/kg Behavioral: Convulsions or effect on seizure threshold AIPTAK 3,77,1897


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 25 ppm/6 hour/26 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JEPOEC 5(4/5),151,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD air time-weighted average 10 ppm DTLWS* 3,14,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 ppm CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 ppm CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 10 ppm (20 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (20 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 10 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (21 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 10 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (4 mg/m3), VLE 10 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 10 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 20 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (22 mg/m3), KZG- week 50 ppm (110 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (22 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 10 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 10 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYANOGEN-air 10 hour time-weighted average 10 ppm NIOSH* DHHS #95-121,1995


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101207/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in organic syntheses, was once used in poison gas warfare
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used as an intermediate in organic syntheses, was once used in poison gas warfare

NIOSH PROFILE (CYANOGEN), SRC, 12/79

RTECS Compound Description:
   Human Data
   Primary Irritant

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