The Registry of Toxic Effects of Chemical Substances

Cyclohexane, 1,2,3,4,5,6 - hexachloro -

RTECS #: GV3150000

CAS #: 608-73-1

UPDATE: November 2004 MW: 290.82 MF: C6H6Cl6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,2,3,4,5,6 - Hexachlorocyclohexane
  2. BHC
  3. Benzene hexachloride
  4. ENT 8,601
  1. HCH
  2. Hexachlorocyclohexane
  3. Hexachlorocyclohexane technical
  4. Latka 666 (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) MILEDM 5,103,1977
morphological transform oral
rat 		875 mg/kg/7 week- intermittent CRNGDP 5,479,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 9,120 mg/kg (22 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) BECTA6 26,508,1981
oral
mouse 		lowest published toxic dose: 5,460 mg/kg (91 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct BECTA6 23,431,1979
oral
rat 		lowest published toxic dose: 8,100 mg/kg (90 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct APTOA6 52,12,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 6,720 mg/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors 		JPFCD2 14,305,1979
oral
mouse 		toxic dose : 800 mg/kg/80 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Tumors 		JPFCD2 14,305,1979
oral
mouse 		toxic dose : 12,600 mg/kg/30 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		JCROD7 99,143,1981
oral
mouse 		toxic dose : 12,960 mg/kg/26 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		CMSHAF 1,279,1972
oral
mouse 		toxic dose : 21,600 mg/kg/52 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		TUMOAB 69,383,1983
oral
mouse 		toxic dose : 5,400 mg/kg/13 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		TUMOAB 69,383,1983
oral
mouse 		toxic dose : 7,200 mg/kg/17 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		IJEBA6 19,1159,1981
oral
mouse 		toxic dose : 9 gm/kg/21 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		AEHLAU 37,156,1982
oral
mouse 		toxic dose : 10,800 mg/kg/26 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		AEHLAU 37,156,1982
oral
mouse 		toxic dose : 7,200 mg/kg/17 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		CMBID4 27,231,1981
oral
mouse 		toxic dose : 10,800 mg/kg/26 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		CMBID4 27,231,1981
skin
mouse 		lowest published toxic dose: 1,600 mg/kg/80 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Tumors 		JPFCD2 14,305,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 25 mg/m3/6 hour N/R VCVGH* -,537,1990
inhalation
man 		lowest published toxic concentration: 400 µg/kg/3 day Behavioral: Headache

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Body temperature increase 		GISAAA 49(10),26,1984
inhalation
rat 		lethal concentration (50 percent kill): 690 mg/m3/4 hour N/R GISAAA 56(2),80,1991
oral
wild bird 		lethal dose (50 percent kill): 56 mg/kg N/R TXAPA9 21,315,1972
oral
cat 		lethal dose (50 percent kill): 300 mg/kg N/R VCVGH* -,537,1990
oral
chicken 		lethal dose (50 percent kill): 597 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		POSCAL 60,2599,1981
oral
guinea pig 		lowest published lethal dose: 1,400 mg/kg N/R MEMOAQ 4,25,1950
oral
mouse 		lethal dose (50 percent kill): 59 mg/kg N/R PEMNDP 9,452,1991
oral
quail 		lethal dose (50 percent kill): 120 mg/kg N/R PEMNDP 9,452,1991
oral
rat 		lethal dose (50 percent kill): 100 mg/kg N/R ATXKA8 22,115,1966
oral
rat 		lowest published lethal dose: 400 mg/kg N/R VCVGH* -,537,1990
subcutaneous
rabbit 		lethal dose (50 percent kill): 75 mg/kg N/R XPHPAW 414,273,1955
skin
rat 		lethal dose (50 percent kill): 900 mg/kg N/R 85DPAN -,-,1971/1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rabbit 		lowest published toxic dose: 650 mg/kg/65 week- intermittent Eye: Retinal changes pigmentary deposition, retinitis, other)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Conditioned vitamin deficiency 		JTOTDO 6,161,1987
oral
mouse 		lowest published toxic dose: 750 mg/kg/15 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		BECTA6 41,822,1988
oral
mouse 		lowest published toxic dose: 13,104 mg/kg/26 week- continuous Liver: Other changes

Liver: Tumors

Liver: Changes in liver weight 		CMSHAF 1,279,1972
oral
rat 		lowest published toxic dose: 2,500 mg/kg/90 day- continuous Liver: Other changes

Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		IJEBA6 19,1163,1981
oral
rat 		lowest published toxic dose: 2,259 mg/kg/90 day- continuous Behavioral: Tremor

Liver: Hepatitis (hepatocellular necrosis), diffuse

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JAPTO* 21,75,2001
oral
rat 		lowest published toxic dose: 4,500 mg/kg/90 day- continuous Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Changes in cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		JAPTO* 21,75,2001
skin
guinea pig 		lowest published toxic dose: 3 gm/kg/30 day- intermittent Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		JTOTDO 11,3,1992
skin
rat 		lowest published toxic dose: 6,000 mg/kg/120 day- intermittent Endocrine: Androgenic

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		HETOEA 14,484,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 5,47,1974
TOXICOLOGY REVIEW
AABIAV 35,505,1948
TOXICOLOGY REVIEW
ECMAAI 14,141,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, Skin, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - GERMANY MAK 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.5 mg/m3, short term exposure limit 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.4 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 10th Report on Carcinogens,2002:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
AABIAV Annals of Applied Biology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1914-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CMBID4 Cellular and Molecular Biology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.22- 1977-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
ECMAAI Economie et Medecine Animales. (Paris, France) V.1-17, 1960-76. Discontinued.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93- 1979-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
MEMOAQ Medizinische Monatsschrift. (Stuttgart, Fed. Rep. Ger.) V.1-31, 1947-77.
MILEDM Microbios Letters. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1976-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
POSCAL Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark St., Champaign, IL 61820) V.1- 1921-
TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan, Italy) V.1- 1911-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
XPHPAW U.S. Public Health Service Publication. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1950-

Used as an agricultural chemical and pesticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

 Click Here for Additional Information about RTECS