The Registry of Toxic Effects of Chemical Substances

Cyclohexane, 1,2,3,4,5,6 - hexachloro - , beta - isomer

RTECS #: GV4375000

CAS #: 319-85-7

UPDATE: May 2005 MW: 290.82 MF: C6H6Cl6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - alpha,2 - beta,3 - alpha,4 - beta,5 - alpha,6 - beta - Hexachlorocyclohexane
  2. Beta - Hexachlorocyclohexane
  3. Cyclohexane, 1,2,3,4,5,6 - hexachloro - , beta -
  4. Cyclohexane, 1,2,3,4,5,6 - hexachloro - , trans -
  5. Cyclohexane, beta - 1,2,3,4,5,6 - hexachloro -
  6. ENT 9,233
  7. beta - 1,2,3,4,5,6 - Hexachlorocyclohexane
  1. beta - BHC
  2. beta - HCH
  3. beta - Hexachlorobenzene
  4. beta - Hexachlorocyclohexane
  5. beta - Lindane
  6. trans - alpha - Benzenehexachloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 672 mg/kg (2 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct BECTA6 41,531,1988
subcutaneous
mouse 		lowest published toxic dose: 100 mg/kg (7 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina EVHPAZ 108,973,2000


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 18 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		FCTXAV 11,433,1973


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published lethal dose: 1,500 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		PHTXA6 22,273,1959
oral
rat 		lethal dose (50 percent kill): 6 gm/kg N/R ALLVAR 43,-,1955


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
monkey 		lowest published toxic dose: 2,250 mg/kg/90 day- intermittent Liver: Fatty liver degeneration

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		NYKZAU 70,85P,1974
oral
mouse 		lowest published toxic dose: 9 gm/kg/30 day- continuous Endocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified)

Immunological Including Allergic: Decrease in cellular immune response 		FAATDF 11,293,1988
oral
mouse 		lowest published toxic dose: 13,104 mg/kg/26 week- continuous Liver: Other changes

Liver: Tumors

Liver: Changes in liver weight 		CMSHAF 1,279,1972
oral
mouse 		lowest published toxic dose: 6,048 mg/kg/12 week- continuous Liver: Other changes

Liver: Changes in liver weight 		CMSHAF 1,153,1972
oral
mouse 		lowest published toxic dose: 1,080 mg/kg/30 day- continuous Blood: Changes in spleen HBPTO* 1,771,2001
oral
rat 		lowest published toxic dose: 672 mg/kg/2 week- continuous Liver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		BECTA6 41,531,1988
oral
rat 		lowest published toxic dose: 22,750 mg/kg/13 week- continuous Liver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		FAATDF 6,697,1986
oral
rat 		lowest published toxic dose: 8,736 mg/kg/26 week- continuous Liver: Other changes

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 100,59,1950
oral
rat 		lowest published toxic dose: 1,989 mg/kg/30 day- continuous Peripheral Nerve and Sensation: Recording from peripheral motor nerve BECTA6 27,704,1981
subcutaneous
mouse 		lowest published toxic dose: 100 mg/kg/1 week- continuous Endocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina 		EVHPAZ 108,973,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 20,195,1979
TOXICOLOGY REVIEW
REPTED 19,209,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA MAK 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg/m3, Skin, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/166662)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an insecticide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
ALLVAR Alimentation et la Vie. (Societe Scientifique d'Hygiene Alimentaire, 16, rue de l'Estrapade, 75005 Paris, France) V.39- 1951-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-

Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Reproductive Effector

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