The Registry of Toxic Effects of Chemical Substances

Cyclohexylamine

RTECS #: GX0700000

CAS #: 108-91-8

UPDATE: November 2004 MW: 99.20 MF: C6H13N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Aminocyclohexane
  2. Aminohexahydrobenzene
  3. Aniline, hexahydro -
  4. Benzenamine, hexahydro -
  5. CHA
  1. Cyclohexanamine
  2. Cyclohexylamine (ACGIH)
  3. Hexahydrobenzenamine
  4. Hexahydroaniline


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 µg/24 hour severe 85JCAE -,454,1986
eye
rabbit 		100 µL/5 minute severe NTIS** OTS0540890
skin
human 		125 mg/48 hour severe AMIHBC 5,311,1952
skin
rabbit 		2 mg/24 hour severe 85JCAE -,454,1986
skin
rabbit 		500 µL severe NTIS** OTS0540890


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis unreported route
domestic animal 		50 mg/kg MUREAV 26,407,1974
cytogenetic analysis hamster fibroblast 10 mg/L MUREAV 39,1,1976
cytogenetic analysis human leukocyte 10 µmol/L/5 hour MUREAV 39,1,1976
cytogenetic analysis mammal (species unspecified) kidney 50 mg/L/8 hour- continuous FCTXAV 8,617,1970
cytogenetic analysis intraperitoneal
rat 		5 mg/kg/5 day- continuous SCIEAS 165,1139,1969
dominant lethal test intraperitoneal
mouse 		500 mg/kg/5 day- intermittent MUREAV 14,126,1972
DNA inhibition human HeLa cell 100 µg/L INHEAO 9,188,1971
host-mediated assay hamster
leukocyte 		450 mg/kg/3 day- continuous MUREAV 31,5,1975
morphological transform hamster embryo 60 mg/L AETODY 1,241,1980
specific locus test intraperitoneal
mouse 		200 mg/kg PCBRD2 109,339,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 61 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 4,141,1971
intraperitoneal
mouse 		lowest published toxic dose: 77 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TJADAB 4,141,1971
intraperitoneal
mouse 		lowest published toxic dose: 200 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Other measures of fertility PCBRD2 109,339,1982
intraperitoneal
rat 		lowest published toxic dose: 300 mg/kg (1 day male) Reproductive: Effects on fertility: Other measures of fertility FCTXAV 10,29,1972
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg (1 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) FCTXAV 10,29,1972
oral
dog 		lowest published toxic dose: 14 gm/kg (8 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) FCTXAV 19,291,1981
oral
dog 		lowest published toxic dose: 15,750 mg/kg (9 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct FCTXAV 19,291,1981
oral
mouse 		lowest published toxic dose: 600 mg/kg (6-11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		SEIJBO 11,51,1971
oral
mouse 		lowest published toxic dose: 120 mg/kg (6-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) SEIJBO 11,51,1971
oral
rat 		lowest published toxic dose: 5,600 mg/kg (4 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) FCTXAV 19,291,1981
parenteral
mouse 		lowest published toxic dose: 250 mg/kg (5 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) AMESES 1,33,1970
unreported route
rat 		lowest published toxic dose: 5 mg/kg (1 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) AMESES 1,25,1970


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 1,200 ppm/7 hour Lung, Thorax, or Respiration: Other changes IMSUAI 19,317,1950
inhalation
mouse 		lethal concentration (50 percent kill): 1,070 mg/m3 Behavioral: Excitement

Behavioral: Muscle contraction or spasticity 		GTPZAB 7(11),51,1963
inhalation
rat 		lethal concentration (50 percent kill): 7,500 mg/m3 Behavioral: Excitement

Behavioral: Muscle contraction or spasticity 		GTPZAB 7(11),51,1963
inhalation
rabbit 		lowest published lethal concentration: 150 ppm/7 hour N/R IMSUAI 19,317,1950
intraperitoneal
mammal (species unspecified) 		lethal dose (50 percent kill): 200 mg/kg Brain and Coverings: Other degenerative changes

Vascular: Shock

Liver: Other changes 		AMIHBC 5,311,1952
intraperitoneal
mouse 		lethal dose (50 percent kill): 129 mg/kg N/R PCJOAU 22,469,1988
intraperitoneal
rat 		lethal dose (50 percent kill): 300 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		NYKZAU 65(1),53S,1969
intravenous
dog 		lethal dose (50 percent kill): 200 mg/kg Behavioral: Convulsions or effect on seizure threshold NYKZAU 65(1),53S,1969
intravenous
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R IPSTB3 3,93,1976
oral
mouse 		lethal dose (50 percent kill): 224 mg/kg N/R 85GMAT -,41,1982
oral
rat 		lethal dose (50 percent kill): 11 mg/kg Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Pulmonary emboli

Gastrointestinal: Other changes 		NTIS** OTS0534836
parenteral
rabbit 		lowest published lethal dose: 500 mg/kg Behavioral: Convulsions or effect on seizure threshold IECHAD 29,1247,1937
subcutaneous
mouse 		lethal dose (50 percent kill): 1,150 mg/kg N/R VOONAW 4,659,1958
skin
rabbit 		lethal dose (50 percent kill): 320 µL/kg N/R AIHAAP 30,470,1969
unreported route
mouse 		lethal dose (50 percent kill): 770 mg/kg N/R TXAPA9 14,654,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 700 mg/m3/2 hour/9 week- intermittent Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GTPZAB 7(11),51,1963
inhalation
rat 		lowest published toxic concentration: 100 mg/m3/4 hour/22 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in cell count (unspecified)

Nutritional and Gross Metabolic: Other changes 		GTPZAB 7(11),51,1963
oral
rat 		lowest published toxic dose: 35,700 mg/kg/1 year- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VOONAW 4,659,1958
oral
rat 		lowest published toxic dose: 1,200 mg/kg/3 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		EXMPA6 52,155,1990
oral
rat 		lowest published toxic dose: 2,800 mg/kg/1 week- continuous Related to Chronic Data: Changes in testicular weight EXMPA6 52,155,1990
oral
rat 		lowest published toxic dose: 8,400 mg/kg/3 week- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		EXMPA6 52,155,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMSUDL 7,178,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal NO EVIDENCE IMEMDT 22,55,1980
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 22,55,1980
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,178,1987
TOXICOLOGY REVIEW
MUREAV 39,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (40 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 10 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (41 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (40 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 10 ppm (40 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (40 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 10 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, Skin, 2003
Occupational Exposure Limit - POLAND time-weighted average 40 mg/m3, short term exposure limit 80 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (40 mg/m3), KZG- week 20 ppm (80 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (41 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXYLAMINE-air 10 hour time-weighted average 10 ppm NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84526;
Number of Industries 63;
Total Number of Facilities 3,468;
Number of Occupations 25;
Total Number of Employees Exposed 9,450
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84526;
Number of Industries 83;
Total Number of Facilities 4,729;
Number of Occupations 47;
Total Number of Employees Exposed 64,346;
Total Number of Female Employees Exposed 2,914


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Cytogenetics-male germ cell
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; Host-mediated assay
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in water treatment, also used in rubber production to retard degradation
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMESES Abstracts of the Annual Meeting, Environmental Mutagen Society. (Environmental Mutagen Soc., 1340 Old Chain Bridge Rd., Suite 300, McLean, VA 22101)
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1975-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-

Used in water treatment, also used in rubber production to retard degradation

NIOSH PROFILE (AMINES, PRIMARY AROMATIC), SRI, 2/77

NIOSH PROFILE (CYCLOHEXYLAMINE), SRC, 12/79

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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